177795-78-7Relevant articles and documents
Thrombin inhibitors
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Page column 27, (2010/02/06)
Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy
Tucker, Thomas J.,Lumma, William C.,Lewis, S. Dale,Gardell, Stephen J.,Lucas, Bobby J.,Baskin, Elizabeth P.,Woltmann, Richard,Lynch, Joseph J.,Lyle, Elizabeth A.,Appleby, Sandra D.,Chen, I.-Wu,Dancheck, Kimberley B.,Vacca, Joseph P.
, p. 1565 - 1569 (2007/10/03)
In an effort to prepare orally bioavailable analogs of our previously reported thrombin inhibitor 1, we have synthesized a series of compounds that utilize the unique amino acid D-dicyclohexylalanine as a P3 ligand. The resulting compounds are extremely p
