1778-74-1

Basic information

• Product Name: 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine
• Synonyms: 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine;2-(1H-PYRROLO[3,2-C]PYRIDIN-3-YL)ETHANAMINE
• CAS NO: 1778-74-1
• Molecular Formula: C₉H₁₁N₃
• Molecular Weight: 161.20374
• Mol File: 1778-74-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 375.984°C at 760 mmHg
• Flash Point: 209.12°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.68
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.40±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine(1778-74-1)
• EPA Substance Registry System: 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine(1778-74-1)

Safety Data

• Hazardous Substances Data: 1778-74-1(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[3,2-c]pyridine-3-ethanamine is a chemical compound with the molecular formula C9H10N2. It is a heterocyclic amine with a fused pyrrole and pyridine ring system. 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine can be used in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity. It has been studied for its potential biological and pharmacological activities, including as an antitumor agent, an antidepressant, and an antiviral agent. Additionally, 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine may have applications in materials science and organic chemistry as a building block for the synthesis of complex molecules and polymers.

InChI:InChI=1/C9H11N3/c10-3-1-7-5-12-9-2-4-11-6-8(7)9/h2,4-6,12H,1,3,10H2

Upstream product

• 183208-19-7 N-<2-<2-trimethylsilyl-1H-pyrrolo<3,2-c>pyridin-3-yl>ethyl>acetamide 
• 88511-27-7 3-iodopyridin-4-amine 
• 1336-21-6 ammonium hydroxide 
• 39676-14-7 2-(1H-pyrrolo[3,2-c]pyridin-3-yl)acetonitrile 
• 1378780-41-6 2-oxo-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)-acetamide 
• 271-34-1 5-azaindole 

Downstream Products

• 1312891-88-5 (E)-3-(4-{[2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethylamino]methyl}phenyl)acrylic acid methyl ester 
• 1312891-50-1 (E)-N-hydroxy-3-(4-{[2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethylamino]methyl}phenyl)acrylamide 

Relevant articles and documents

Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors

Histone deacetylase (HDAC) inhibitors have shown promise in treating various forms of cancer. However, many HDAC inhibitors from diverse structural classes have been associated with QT prolongation in humans. Inhibition of the human ether a-go-go related gene (hERG) channel has been associated with QT prolongation and fatal arrhythmias. To determine if the observed cardiac effects of HDAC inhibitors in humans is due to hERG blockade, a highly potent HDAC inhibitor devoid of hERG activity was required. Starting with dacinostat (LAQ824), a highly potent HDAC inhibitor, we explored the SAR to determine the pharmacophores required for HDAC and hERG inhibition. We disclose here the results of these efforts where a high degree of pharmacophore homology between these two targets was discovered. This similarity prevented traditional strategies for mitigating hERG binding/modulation from being successful and novel approaches for reducing hERG inhibition were required. Using a hERG homology model, two compounds, 11r and 25i, were discovered to be highly efficacious with weak affinity for the hERG and other ion channels.

Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.