177843-72-0

Basic information

• Product Name: 1H-Benzimidazol-5-amine, 6-methyl- (9CI)
• Synonyms: 1H-Benzimidazol-5-amine, 6-methyl- (9CI);6-Methyl-1H-benzo[d]iMidazol-5-aMine;5-methyl-1H-benzo[d]imidazol-6-amine 6-methyl-3H-benzo[d]imidazol-5-amine 1H-Benzimidazol-5-amine, 6-methyl- (9CI);5-methyl-1H-Benzimidazol-6-amine
• CAS NO: 177843-72-0
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.17716
• Product Categories: BENZIMIDAZOLE
• Mol File: 177843-72-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazol-5-amine, 6-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-5-amine, 6-methyl- (9CI)(177843-72-0)
• EPA Substance Registry System: 1H-Benzimidazol-5-amine, 6-methyl- (9CI)(177843-72-0)

Safety Data

• Hazardous Substances Data: 177843-72-0(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazol-5-amine, 6-methyl- (9CI) is a chemical compound with the molecular formula C8H9N3. It is a derivative of benzimidazole, a heterocyclic aromatic organic compound. This chemical is of interest to researchers due to its potential applications in pharmaceuticals and agrochemicals. It is also used in the synthesis of various organic compounds. 1H-Benzimidazol-5-amine, 6-methyl- (9CI) is known to have several biological activities and has been studied for its potential as a drug target for various diseases. Overall, this chemical compound has important implications in the field of organic chemistry and medicinal research.

Upstream product

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Relevant articles and documents

Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity

The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented,

Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor

Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human immunodeficiency virus (HIV). This is particularly true for the growing number of patients infected with virus resistant to currently approved HIV drugs. Our high throughput screening effort identified a benzophenone template as a potential nonnucleoside reverse transcriptase inhibitor (NNRTI). This manuscript describes our extensive exploration of the benzophenone structure-activity relationships, which culminated in the identification of several compounds with very potent inhibition of both wild type and clinically relevant NNRTI-resistant mutant strains of HIV. These potent inhibitors include 70h (GW678248), which has in vitro antiviral assay IC50 values of 0.5 nM against wild-type HIV, 1 nM against the K103N mutant associated with clinical resistance to efavirenz, and 0.7 nM against the Y181C mutant associated with clinical resistance to nevirapine. Compound 70h has also demonstrated relatively low clearance in intravenous pharmacokinetic studies in three species, and it is the active component of a drug candidate which has progressed to phase 2 clinical studies.