1779-49-3 Usage
Description
Methyltriphenylphosphonium bromide is an organophosphorus compound, characterized by its white powder appearance. It is a lipophilic molecule with a cation, which allows it to be used for delivering molecules to specific cell components. This property, along with its potential as an antineoplastic agent, makes it a versatile compound in various applications.
Uses
Used in Pharmaceutical Industry:
Methyltriphenylphosphonium bromide is used as a PTC (Phase Transfer Catalyst) for facilitating chemical reactions in both aqueous and non-aqueous phases, which is crucial in the synthesis of various pharmaceutical compounds.
Used in Organic Synthesis:
Methyltriphenylphosphonium bromide is used as a reagent in the Wittig reaction for methylenation, a key step in the synthesis of complex organic molecules such as enynes and 9-isopropenyl-phenanthrenes. Its lipophilic nature aids in delivering molecules to specific cell components, making it a valuable tool in organic synthesis.
Used in Antineoplastic Applications:
Methyltriphenylphosphonium bromide is used as an antineoplastic agent, potentially contributing to the development of novel cancer treatments by targeting and delivering therapeutic molecules to cancer cells.
Used in Calibration of Melting Point Instruments:
Methyltriphenylphosphonium bromide serves as a calibration substance (ME 30130598) for the regular calibration of Mettler-Toledo melting point instruments, ensuring accurate and reliable measurements in various scientific and industrial applications.
Purification Methods
If the solid is sticky, wash it with *C6H6 and dry it in a vacuum over P2O5. [Marvel & Gall J Org Chem 24 1494 1959, Chem Ber 87 1318 1954, Milas & Priesing J Am Chem Soc 79 6295 1957, Wittig & Sch.llkopf Org Synth 40 66 1960.] The iodide, on recrystallisation from H2O, has m 187.5-188.5o [Mann et al. J Chem Soc 1130 1953, Wittig & Geissler Justus Liebigs Ann Chem 580 44 1953]. [Beilstein 16 IV 981.]
Check Digit Verification of cas no
The CAS Registry Mumber 1779-49-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,7 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1779-49:
(6*1)+(5*7)+(4*7)+(3*9)+(2*4)+(1*9)=113
113 % 10 = 3
So 1779-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H15P.CH3Br/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;1-2/h1-15H;1H3/p+1
1779-49-3Relevant articles and documents
Stereospecific total synthesis of (+) ε and (-) γ2 cadinene
Burk,Soffer
, p. 2083 - 2087 (1976)
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Warren Jun.,Hawthorne
, p. 4823,4827 (1968)
Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes
Li, Quanzhe,Liu, Jiaxin,Shi, Min,Wei, Yin
supporting information, (2020/03/26)
In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.
Practical synthesis of phosphonium salts with orthoformates and their application as flame retardants in polycarbonate
Jiang, Pingkai,Li, Tao,Xu, Chencong,Zhang, Yong Jian
, (2020/03/23)
An efficient and practical approach to phosphonium salts has been developed. By the reaction of phosphines and different acid sources with orthoformates in one-step operation, the process allowed rapid access to phosphonium salts with diverse counterions in high yield after the purification by recrystallization. The flame retardant performance in PC has also been examined by blending several phosphonium salts to PC respectively. Phosphonium phosphates showed excellent flame retardancy in PC with only 2 phr blending.