177949-07-4

Basic information

• Product Name: 5-O-benzoyl-1,2-di-O-acetyl-3-O-methanesulfonyl-α/β-D-xylofuranose
• Synonyms: 5-O-benzoyl-1,2-di-O-acetyl-3-O-methanesulfonyl-α/β-D-xylofuranose
• CAS NO: 177949-07-4
• Molecular Weight: 416.406
• Mol File: 177949-07-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-O-benzoyl-1,2-di-O-acetyl-3-O-methanesulfonyl-α/β-D-xylofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 5-O-benzoyl-1,2-di-O-acetyl-3-O-methanesulfonyl-α/β-D-xylofuranose(177949-07-4)
• EPA Substance Registry System: 5-O-benzoyl-1,2-di-O-acetyl-3-O-methanesulfonyl-α/β-D-xylofuranose(177949-07-4)

Safety Data

• Hazardous Substances Data: 177949-07-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 190003-75-9 5-O-benzoyl-1,2-O-isopropylidene-3-O-methylsulfonyl-α-D-xylofuranose 
• 98-88-4 benzoyl chloride 
• 16848-28-5 1,2-O-isopropylidene-3-O-methanesulfonyl-α-D-glucofuranose 
• 74580-95-3 1,2-O-isopropylidene-3-O-mesyl-α-D-xylofuranose 
• 5450-26-0 1,2,5,6-di-O-isopropylidene-3-O-methylsulfonyl-α-D-glucofuranose 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 532-20-7 D-xylofuranose 
• 64-19-7 acetic acid 

Downstream Products

• 190003-84-0 1-(5'-O-benzoyl-2',3'-di-O-methylsulfonyl-β-D-xylofuranosyl)thymine 
• 190003-86-2 2,2'-anhydro-1-(5'-O-benzoyl-3'-O-methylsulfonyl-β-D-lyxofuranosyl)thymine 
• 190003-82-8 1-(5-O-benzoyl-3-O-mesyl-β-D-xylofuranosyl)thymine 
• 3056-17-5 stavudin 
• 122567-97-9 5′-benzoyl-2′,3′-didehydro-3′-deoxythymidine 
• 190003-79-3 1-(2'-O-acetyl-5'-O-benzoyl-3'-O-methylsulfonyl-β-D-xylofuranosyl)thymine 
• 177949-08-5 Benzoic acid (2R,3S,4R,5R)-4-acetoxy-3-methanesulfonyloxy-5-(2-oxo-5-phenyl-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Synthesis and comparative evaluation of two antiviral agents: β-L- Fd4C and β-D-Fd4C

The synthesis of β-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of β-D-Fd4C was compared with that of β-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, β-L-Fd4C was found to be the most potent antiviral agent.

Chemical Synthesis of 13C-labelled Monomers for the Solid-Phase and Template Controlled Enzymatic Synthesis of DNA and RNA Oligomers

The preparation of 13C-labelled ribonucleosides starting from -glucose 1 and the corresponding nucleobases 5a-e or 6a-e (N6-benzoyl-adenine, N2-acetyl-guanine, N4-benzoyl-cytosine, uracil and thymine) in 47-66percent overall yield is described.Their subsequent transformation into 5'-O-dimethoxytrityl protected DNA-phosphoramidites and 5'-O-dimethoxytrityl-2'-O-trialkylsilyl protected RNA-phosphor-amidites for the solid phase synthesis of DNA- and RNA-oligomers and to 5'-O-ribo- and deoxyribo-nucleosidetriphosphates for template controlled enzymatic synthesis (polymerase- or reverse transcriptase reaction) has been carried out.