177990-33-9

Basic information

• Product Name: Benzyl N-Boc-4-piperidinecarboxylate
• Synonyms: Benzyl N-Boc-4-piperidinecarboxylate;1,4-Piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester;4-O-benzyl 1-O-tert-butyl piperidine-1,4-dicarboxylate
• CAS NO: 177990-33-9
• Molecular Formula: C₁₈H₂₅NO₄
• Molecular Weight: 319
• Mol File: 177990-33-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 415.5±38.0 °C(Predicted)
• Appearance: /
• Density: 1.128±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.31±0.40(Predicted)
• CAS DataBase Reference: Benzyl N-Boc-4-piperidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl N-Boc-4-piperidinecarboxylate(177990-33-9)
• EPA Substance Registry System: Benzyl N-Boc-4-piperidinecarboxylate(177990-33-9)

Safety Data

• Hazardous Substances Data: 177990-33-9(Hazardous Substances Data)

Usage

General Description

Benzyl N-Boc-4-piperidinecarboxylate is a chemical compound that is commonly used as a reagent in organic synthesis. It is a derivative of piperidine and contains a benzyl group and a Boc (tert-butyloxycarbonyl) protecting group on the nitrogen atom. The Boc protecting group is often used in organic chemistry to protect amines from unwanted reactions and can be easily removed under mild conditions to reveal the free amine functional group. Benzyl N-Boc-4-piperidinecarboxylate is often used in the preparation of pharmaceuticals, agrochemicals, and other bioactive compounds due to its versatile reactivity and ability to be selectively deprotected to reveal the piperidine backbone.

Upstream product

• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 280115-99-3 tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate 
• 498-94-2 isonipecotic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-44-7 benzyl chloride 

Downstream Products

• 103824-89-1 (+)-piperidine-4-carboxylic acid benzyl ester 
• 336190-98-8 benzyl 1-(3-ethoxy-3-oxopropanoyl)-4-piperidine carboxylate 
• 296240-48-7 benzyl 1-tert-butoxycarbonyl-4-methyl-4-piperidinecarboxylate 
• 951744-79-9 4-benzyloxycarbonyl-1-tert-butoxycarbonyl-4-piperidinecarboxylic acid 
• 1334679-08-1 4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 1334678-31-7 1-(2-(S)-amino-3-thiophen-2-yl-propionyl)-4-(4-dimethylcarbamoyl-benzyl)-piperidine-4-carboxylic acid cyclohexylamide hydrochloride 
• 1334679-09-2 4-(4-methoxycarbonyl-benzyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 1334679-11-6 4-(4-cyclohexylcarbamoyl-piperidin-4-ylmethyl)-benzoic acid methyl ester 
• 1334679-12-7 4-cyclohexylcarbamoyl-4-(4-methoxycarbonyl-benzyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1334679-13-8 4-[1-(2-(S)-tert-butoxycarbonylamino-3-thiophen-2-yl-propionyl)-4-cyclohexylcarbamoyl-piperidin-4-ylmethyl]-benzoic acid methyl ester 
• 1334679-14-9 4-[1-(2-(S)-tert-butoxycarbonylamino-3-thiophen-2-yl-propionyl)-4-cyclohexylcarbamoyl-piperidin-4-ylmethyl]-benzoic acid 
• 177990-54-4 N-t-butoxycarbonyl-4-hydroxymethyl-4-(2-methylbenzyl)-piperidine 
• 198649-40-0 N-tert-butoxycarbonyl-4-(3-methylbenzyl)-isonipecotic acid 

Relevant articles and documents

ANTIBACTERIAL ANTISENSE AGENTS

The invention relates to improved ANTISENSE agents for the treatment of gram-negative bacterial infections. Compounds of the invention utilise an Antibiotic-Assisted Translocation; AAT' platform to improve influx into bacterial cells through enhanced permeability, providing improved intracellular exposure of the ANTISENSE AGENT and superior treatment of the infection.

4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1)

The present invention is directed to 4,4-dl-substjtuted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

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