1780-42-3Relevant articles and documents
1,1,1-TRICHLORO-3--3,4-EPOXYBUTANE
Pews, R. Garth,Puckett, Wallace E.
, p. 179 - 186 (1989)
The synthesis of 1,1,1-trichloro-3--3,4-epoxybutane has been accomplished in nine steps from diethyl malonate and urea.The epoxide was prepared from the olefinic precursor via oxidation with anhydrous trifluoroperacetic acid in a non-buffered system.Product isolation from trifluoroacetic acid solution demonstrates an unexpected stability of this class of epoxides toward protonic media.
HETEROCYCLIC INHIBITORS OF KDM5 FOR THE TREATMENT OF DISEASE
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Paragraph 0355; 0356, (2018/12/12)
The present invention relates to compounds and methods useful as inhibitors of KDM5 for the treatment or prevention of cancer.
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Mitchell, Michael L.,Son, Jong Chan,Guo, Hongyan,Im, Yun-A,Cho, Eun Jung,Wang, Jianhong,Hayes, Jaclyn,Wang, Michael,Paul, Amber,Lansdon, Eric B.,Chen, James M.,Graupe, Doris,Rhodes, Gerry,He, Gong-Xin,Geleziunas, Romas,Xu, Lianhong,Kim, Choung U.
scheme or table, p. 1589 - 1592 (2010/06/19)
A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics