178032-64-9

Basic information

• Product Name: (R)-(+)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-(+)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 178032-64-9
• Molecular Weight: 269.343
• Mol File: 178032-64-9.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: (R)-(+)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline(178032-64-9)
• EPA Substance Registry System: (R)-(+)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline(178032-64-9)

Safety Data

• Hazardous Substances Data: 178032-64-9(Hazardous Substances Data)

Upstream product

• 4029-09-8 6,7-dimethoxy-1-phenyl-isoquinoline 
• 10172-51-7 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline 
• 20922-03-6 1-(propan-2-yl)isoquinoline 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 98-88-4 benzoyl chloride 
• 4118-36-9 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 1643770-97-1 (S)-2,2-dimethyl-5-oxo-3-(2-phenylacetyl)imidazolidin-1-yl 2-methoxy-2-phenylacetate 
• 922359-27-1 1-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)pent-4-en-1-one 
• 1346681-71-7 (1E)-4-hydroxy-1-mesityl-4-methylpent-1-en-3-one 
• 1017594-90-9 (1R)-1-phenyl-N-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 100-52-7 benzaldehyde 

Downstream Products

• 4118-36-9 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 853650-66-5 (-)-2-(hept-6-ynyl)-6,7-dimethoxy-1R-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 853650-68-7 (-)-6,7-dimethoxy-2-(oct-7-ynyl)-1R-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

A through halogen bond activation isoquinoline asymmetric hydrogenation method

A through halogen bond activation isoquinoline asymmetric hydrogenation method, the catalyzing system is [...] complex, the activator is a halide. The reaction can be carried out under the following conditions, temperature: 25 - 100 °C; solvent: tetrahydr

A method catalyzed by iridium and used for bidirectional enantioselective synthesis of chiral tetrahydroisoquinoline

A method catalyzed by iridium and used for bidirectional enantioselective synthesis of chiral tetrahydroisoquinoline is provided. A catalysis system adopted by the method is a chiral diphosphine complex of iridium. By utilizing a single chiral source and

Flow chemistry and polymer-supported pseudoenantiomeric acylating agents enable parallel kinetic resolution of chiral saturated N-heterocycles

Kinetic resolution is a common method to obtain enantioenriched material from a racemic mixture. This process will deliver enantiopure unreacted material when the selectivity factor of the process, s, is greater than 1; however, the scalemic reaction product is often discarded. Parallel kinetic resolution, on the other hand, provides access to two enantioenriched products from a single racemic starting material, but suffers from a variety of practical challenges regarding experimental design that limit its applications. Here, we describe the development of a flow-based system that enables practical parallel kinetic resolution of saturated N-heterocycles. This process provides access to both enantiomers of the starting material in good yield and high enantiopurity; similar results with classical kinetic resolution would require selectivity factors in the range of s = 100. To achieve this, two immobilized quasienantiomeric acylating agents were designed for the asymmetric acylation of racemic saturated N-heterocycles. Using the flow-based system we could efficiently separate, recover and reuse the polymer-supported reagents. The amide products could be readily separated and hydrolysed to the corresponding amines without detectable epimerization.