178210-71-4

Basic information

• Product Name: (2-Amino-phenyl)-benzo[1,3]dioxol-5-yl-methanone
• Synonyms: (2-Amino-phenyl)-benzo[1,3]dioxol-5-yl-methanone
• CAS NO: 178210-71-4
• Molecular Weight: 241.246
• Mol File: 178210-71-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-Amino-phenyl)-benzo[1,3]dioxol-5-yl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Amino-phenyl)-benzo[1,3]dioxol-5-yl-methanone(178210-71-4)
• EPA Substance Registry System: (2-Amino-phenyl)-benzo[1,3]dioxol-5-yl-methanone(178210-71-4)

Safety Data

• Hazardous Substances Data: 178210-71-4(Hazardous Substances Data)

Upstream product

• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 1885-29-6 anthranilic acid nitrile 
• 17680-04-5 (3,4-methylenedioxy)phenylmagnesium bromide 
• 178210-55-4 Benzo[1,3]dioxol-5-yl-(2-nitro-phenyl)-methanone 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 

Downstream Products

• 178210-56-5 N-[2-(Benzo[1,3]dioxole-5-carbonyl)-phenyl]-oxalamic acid methyl ester 
• 178210-72-5 3-Benzo[1,3]dioxol-5-yl-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides

The reaction of alkene-tethered trifluoroacetimidoyl chlorides with trialkyl phosphites furnishes 1-amino-2,2,2-trifluoroalkylphosphonates. The products were generated in moderate to good yields, and the scalability of this process was showcased. Partial hydrolysis of the phosphonate moiety was achieved. The cyclization is proposed to occur via formation of an imidoyl phosphonate intermediate that becomes susceptible to nucleophilic attack at nitrogen through the strong electron-withdrawing groups at the imidoyl carbon.

Synthesis of 3-Sulfonylamino Quinolines from 1-(2-Aminophenyl) Propargyl Alcohols through a Ag(I)-Catalyzed Hydroamination, (2 + 3) Cycloaddition, and an Unusual Strain-Driven Ring Expansion

We describe herein a silver-catalyzed conversion of 1-(2-aminophenyl)-propargyl alcohols to 4-substituted 3-tosylaminoquinolines using TsN3 as an amino surrogate. Controlled reactions reveal the pathway consisting of Ag(I)-catalyzed 5-exo-dig cyclization, catalyst-free (2 + 3) cycloaddition, and ring-expansive rearrangement via nitrogen expulsion. As a support study, we show that the cyclic enamines in similar conditions produce amidines via a C - C bond migration. (Chemical Equation Presented).