178310-99-1

Basic information

• Product Name: (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate
• Synonyms: (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate
• CAS NO: 178310-99-1
• Molecular Weight: 304.358
• Mol File: 178310-99-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate(178310-99-1)
• EPA Substance Registry System: (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate(178310-99-1)

Safety Data

• Hazardous Substances Data: 178310-99-1(Hazardous Substances Data)

Usage

Description

(4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate is an organic compound characterized by a cyclohexane ring with two fluorine atoms, a methyl group, and a 4-methylbenzenesulfonate group. It is recognized for its role in organic synthesis and holds potential in the fields of medicinal chemistry and material science.

Uses

Used in Organic Synthesis:
(4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate is used as a reagent for introducing the 4-methylbenzenesulfonate group into other molecules, which is crucial for the synthesis of various compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate serves as an important building block in the development and production of certain drugs, contributing to the creation of novel therapeutic agents.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, this compound is utilized as a key component in the synthesis of various agrochemicals, playing a significant role in the development of products for agricultural applications.
Safety and Handling:
Due to its potential hazards, (4,4-difluorocyclohexyl)methyl 4-methylbenzenesulfonate must be handled and stored according to standard chemical safety procedures to ensure the safety of personnel and the environment.

Upstream product

• 178312-48-6 (4,4-difluorocyclohexyl)methanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 959600-88-5 2-(4,4-difluorocyclohexyl)acetonitrile 
• 1122648-78-5 4-(azidomethyl)-1,1-difluorocyclohexane 
• 858121-94-5 4-(bromomethyl)-1,1-difluorocyclohexane 

Relevant articles and documents

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the β1c, β1i, β5c, and β5i subunits exploit the differences in the substrate-binding channels identified by X-ray crystallography, compounds selectively targeting β2c or β2i could not yet be rationally designed because of the high structural similarity of these two subunits. Here, we report the development, chemical synthesis, and biological screening of a compound library that led to the identification of the β2c- and β2i-selective compounds LU-002c (4; IC50 β2c: 8 nM, IC50 β2i/β2c: 40-fold) and LU-002i (5; IC50 β2i: 220 nM, IC50 β2c/β2i: 45-fold), respectively. Co-crystal structures with β2 humanized yeast proteasomes visualize protein-ligand interactions crucial for subunit specificity. Altogether, organic syntheses, activity-based protein profiling, yeast mutagenesis, and structural biology allowed us to decipher significant differences of β2 substrate-binding channels and to complete the set of subunit-selective proteasome inhibitors.

4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors

We describe here a novel 4-amino-2-cyanopyrimidine scaffold for nonpeptidomimetic cathepsin S selective inhibitors. Some of the synthesized compounds have sub-nanomolar potency and high selectivity toward cathepsin S along with promising pharmacokinetic a

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in th