17833-07-7

Basic information

• Product Name: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE
• Synonyms: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE;BUTTPARK 2\01-44;2-PHENYL-BENZO(D)IMIDAZO(2,1-B)THIAZOLE
• CAS NO: 17833-07-7
• Molecular Formula: C₁₅H₁₀N₂S
• Molecular Weight: 250.3183
• Mol File: 17833-07-7.mol
• Article Data: 33

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE(17833-07-7)
• EPA Substance Registry System: 2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE(17833-07-7)

Safety Data

• Hazardous Substances Data: 17833-07-7(Hazardous Substances Data)

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 70-11-1 α-bromoacetophenone 
• 4570-41-6 1,3-benzoxazol-2-amine 
• 30192-87-1 2-(2-imino-benzothiazol-3-yl)-1-phenyl-ethanone 
• 79889-86-4 2-imino-3-phenacyl-2,3-dihydrobenzothiazole hydrobromide 
• 2769-30-4 2-nitrophenyl thiocyanate 
• 532-27-4 1-chloroacetophenone 
• 98-86-2 acetophenone 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 75-52-5 nitromethane 
• 100-52-7 benzaldehyde 
• 100-41-4 ethylbenzene 
• 19433-17-1 acetophenone O-acetyloxime 
• 613-91-2 acetophenone oxime 

Downstream Products

• 17833-10-2 (2-phenyl-benzo[d]imidazo[2,1-b]thiazol-3-yl)-succinic acid 
• 14956-44-6 3-(4-nitro-phenylazo)-2-phenyl-benzo[d]imidazo[2,1-b]thiazole 
• 17833-08-8 diethyl 1-(2-phenylbenzo[d]imidazo[2,1-b]thiazol-3-yl)hydrazine-1,2-dicarboxylate 
• 17833-15-7 2-(4-nitrophenyl)benzo[d]imidazo[2,1-b]thiazole 
• 17833-13-5 3-nitroso-2-phenylbenzo[d]imidazo[2,1-b]thiazole 
• 17833-14-6 3-nitro-2-(4-nitro-phenyl)-benzo[d]imidazo[2,1-b]thiazole 
• 121060-34-2 3-Dimethylaminomethyl-2-phenylimidazo<2,1-b>benzothiazole 
• 127204-71-1 2-phenylimidazo[2,1-b][1,3]benzothiazole-3-carbaldehyde 
• 66085-32-3 2,3-dibenzoylpyrrolo<2,1-b>benzothiazole 
• 127204-59-5 3-(2-Phenyl-benzo[d]imidazo[2,1-b]thiazol-3-yl)-propionic acid 
• 121060-42-2 3-Cyanomethyl-2-phenylimidazo<2,1-b>benzothiazole 
• 121060-38-6 3-Trimethylaminomethyl-2-phenylimidazo<2,1-b>benzothiazole iodide 
• 121060-47-7 2-Phenylimidazo<2,1-b>benzothiazole-3-acetic acid 
• 81292-42-4 1,3-diphenylthieno<3',4':3,4>pyrrolo<2,1-b>benzothiazole 

Relevant articles and documents

Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents

The binding behaviour between calf thymus DNA and synthesized benzothiazolyl triazolium derivatives as potent antimicrobial agents was explored by means of spectroscopic applications together with molecular docking study at the sub-domain IIA, binding sit

A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-b[benzothiazoles

Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via α-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted

FeCl3/ZnI2-catalyzed synthesis of benzo[D]imidazo[2,1-b]thiazole through aerobic oxidative cyclization between 2-aminobenzothiazole and ketone

The FeCl3/ZnI2-catalyzed aerobic oxidative cyclization between 2-aminobenzothiazole and ketone/chalcone for the synthesis of benzo[d]imidazo[2,1-b]thiazole is described. A variety of fused benzoimidazothiazole derivatives are obtained by this protocol.

Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles

A facile and sustainable approach for the amination of benzothiazoles with KSeCN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles

Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles

We report herein, the design, synthesis and study of anticancer properties of sulfenylated 2-phenylimidazo[1,2-a]pyridines and their analogues. A set of twenty sulfenylated imidazo[1, 2-a]pyridine derivatives were synthesized. Whereby elusive amendments to the imidazo[1,2-a]pyridine motif confer dramatic changes in functional affinity of a novel action to modulate anticancer activity in seven different human cancer cell lines i.e.: MDA MB 231 (breast), HepG2 (liver), Hela (cervical), A549 (lung), U87MG (glioblastoma), SKMEL-28 (skin melanoma) and DU-145 (prostate) by employing MTT assay. Among the series, compounds 4e (naphthalene), 4f (styrene) and 4h (thiomethyl) showed potent activity towards human liver cancer cells HepG2. Cell cycle analysis results revealed that these compounds arrested the cell cycle at G2/M phase and induced apoptosis in human liver cancer cells HepG2. It was further confirmed by Hoechst staining, Measurement of mitochondrial membrane potential (ΔΨm) and Annexin V-FITC assay.