178458-56-5Relevant articles and documents
The effect of catalyst loading and donor ligands in the Mn(III) salen catalysed chiral epoxidation of chromenes: Synthesis of BRL 55834
Bell, David,Davies, Mark R.,Finney, Frances J.L.,Geen, Graham R.,Kincey, Peter M.,Mann, Inderjit S.
, p. 3895 - 3898 (1996)
In the absence of a donor ligand both the reaction rate and product e.e. of the manganese (III) salen catalysed epoxidation of 2,2-dimethyl-6- pentafluoroethylchromene were dependent on the catalyst loading. Isoquinoline N-oxide was the most effective donor ligand, affording highly efficient epoxidations with catalyst loadings of 0.1-0.4 mol%. These findings allowed the realisation of a concise, inexpensive synthesis of BRL 55834.
