17878-42-1

Basic information

• Product Name: Magnesium, bromo[4-[(trimethylsilyl)oxy]phenyl]-
• CAS NO: 17878-42-1
• Molecular Formula: C9H13BrMgOSi
• Molecular Weight: 269.496
• Mol File: 17878-42-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Magnesium, bromo[4-[(trimethylsilyl)oxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Magnesium, bromo[4-[(trimethylsilyl)oxy]phenyl]-(17878-42-1)
• EPA Substance Registry System: Magnesium, bromo[4-[(trimethylsilyl)oxy]phenyl]-(17878-42-1)

Safety Data

• Hazardous Substances Data: 17878-42-1(Hazardous Substances Data)

Upstream product

• 17878-44-3 (4-bromophenoxy)trimethylsilane 
• 7439-95-4 magnesium 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 218618-79-2 (2-Allyl-phenoxy)-trimethyl-silan 
• 120186-58-5 cis-2,2-Dimethyl-3-phenyl-4-<4''-(4-p-hydroxyphenoxy)phenylcyclohex-3-en-1-yl>-7-methoxychroman 
• 173676-52-3 4-{7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2H-chromen-2-yl}-phenol 
• 2915-36-8 α,ω-bis(4-hydroxyphenyl)dimethylsilane 
• 188824-33-1 4-[3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6H-5-oxa-11-thia-benzo[a]fluoren-6-yl]-phenol 
• 188824-35-3 (2-{4-[3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6H-5-oxa-11-thia-benzo[a]fluoren-6-yl]-phenoxy}-ethyl)-dimethyl-amine 
• 188824-55-7 (2-{4-[3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6H-5-oxa-11-thia-benzo[a]fluoren-6-yl]-phenoxy}-ethyl)-diethyl-amine 
• 188824-34-2 1-(2-{4-[3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6H-5-oxa-11-thia-benzo[a]fluoren-6-yl]-phenoxy}-ethyl)-pyrrolidine 
• 188824-56-8 4-(2-{4-[3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6H-5-oxa-11-thia-benzo[a]fluoren-6-yl]-phenoxy}-ethyl)-morpholine 
• 188824-36-4 1-(2-{4-[3,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6H-5-oxa-11-thia-benzo[a]fluoren-6-yl]-phenoxy}-ethyl)-pyrrolidin-2-one 
• 501-92-8 4-(prop-2-enyl)phenol 
• 18036-81-2 trimethyl-(4-trimethylsilanyloxy-phenyl)-silane 
• 134414-14-5 11beta-(4-hydroxyphenyl)-estra-4,9-diene-3,17-dione 

Relevant articles and documents

Synthesis and preliminary evaluation steroidal antiestrogen-geldanamycin conjugates

Three novel steroidal antiestrogen-geldanamycin conjugates were prepared using a convergent strategy. The antiestrogenic component utilized the 11β-(4-functionalized-oxyphenyl) estradiol scaffold, while the geldanamycin component was derived by replacement of the 17-methoxy group with an appropriately functionalized amine. Ligation was achieved in high yield using azide alkyne cyclization reactions. Evaluation of the products against two breast cancer cell lines indicated that the conjugates retained significant antiproliferative activity.