17878-54-5

Basic information

• Product Name: AFLATOXIN B2A
• Synonyms: (6as-(6a-alpha,8-beta,9a-alpha))-hexahydro-8-hydroxy-4-methoxy;2’:4,5)furo(2,3-h)(1)benzopyran-1,11-dione,2,3,6a,8,9,9a-cyclopenta(c)furo(3;aflatoxinb1,hemiacetal;aflatoxinb2a;dihydrohydroxy-aflatoxinb;[6aS-(6aalpha,8beta,9aalpha)]-2,3,6a,8,9a-hexahydro-8-hydroxy-4-methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione;AFB2A;(6aS)-2,3,6aα,8,9,9aα-Hexahydro-8β-hydroxy-4-methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione
• CAS NO: 17878-54-5
• Molecular Formula: C₁₇H₁₄O₇
• Molecular Weight: 330.28886
• EINECS: 241-832-6
• Mol File: 17878-54-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 575.2°Cat760mmHg
• Flash Point: 218°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 4.54E-14mmHg at 25°C
• Refractive Index: 1.684
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AFLATOXIN B2A(CAS DataBase Reference)
• NIST Chemistry Reference: AFLATOXIN B2A(17878-54-5)
• EPA Substance Registry System: AFLATOXIN B2A(17878-54-5)

Safety Data

• Hazard Codes: T+
• Statements: 45-46-26/27/28
• Safety Statements: 53-22-36/37/39-45
• RIDADR: 3172
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 17878-54-5(Hazardous Substances Data)

Usage

General Description

Aflatoxin B2a is a naturally occurring mycotoxin produced by certain strains of fungi, particularly Aspergillus flavus and Aspergillus parasiticus. It is commonly found in food and feed commodities such as corn, peanuts, and cottonseed. Aflatoxin B2a is considered a potent carcinogen and can cause liver damage, immune system suppression, and other adverse health effects in animals and humans. It is regulated by various food safety authorities and its presence in food and feed is strictly monitored to ensure consumer safety. Effective control measures, including proper storage and processing techniques, as well as regular monitoring and testing, are essential in minimizing the risk of exposure to aflatoxin B2a.

InChI:InChI=1/C17H14O7/c1-21-9-5-10-14(7-4-11(19)23-17(7)22-10)15-13(9)6-2-3-8(18)12(6)16(20)24-15/h5,7,11,17,19H,2-4H2,1H3/t7-,11+,17-/m0/s1

Upstream product

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Downstream Products

• 1162-65-8 aflatoxin B₁ 

Relevant articles and documents

Antimicrobial aflatoxins from the marine-derived fungus Aspergillus flavus 092008

A new aflatoxin, aflatoxin B2b (1), together with six known compounds, were isolated from the marine-derived fungus Aspergillus flavus 092008 endogenous with the mangrove plant Hibiscus tiliaceus (Malvaceae). The structure of 1 was determined by the spectroscopic and chemical methods. Compound 1 exhibited a moderate antimicrobial activity against Escherichia coli, Bacillus subtilis and Enterobacter aerogenes, with MIC values of 22.5, 1.7 and 1.1 μM, respectively. Compound 1 also showed a weak cytotoxicity against A549, K562 and L-02 cell lines, with IC50 values of 8.1, 2.0 and 4.2 μM, respectively. The results showed that hydration and hydrogenation of Δ8-double bond significantly reduces the cytotoxicity of aflatoxins, while the esterification at C-8 increases the cytotoxicity.

Photodegradation kinetics and byproducts identification of the Aflatoxin B1 in aqueous medium by ultra-performance liquid chromatography- quadrupole time-of-flight mass spectrometry

A photodegradation study of Aflatoxin B1 (AFB1) in water solution was performed under UV irradiation at different AFB1 initial concentrations and UV irradiation intensities. The effect of UV intensity on the AFB1 photodegradation ratio isdominative, when compared with AFB1 initial concentration. The photodegradation of AFB1 was proved to follow first-order reaction kinetics (R 2 ≥ 0.99). Three photodegradation products, i.e. P1 (C17H14O7), P2 (C16H 14O6) and P3 (C16H 12O7), were identified on the basis of low mass error and high matching property by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS), and the degradation pathway was proposed. This study first reports the appearance of these photodegradation products and the proposed degradation pathway in aqueous media. Copyright

A strip liposome immunoassay for aflatoxin B1.

A technique has been developed for the preparation of aflatoxin B1 (AFB1)-tagged liposomes encapsulating a visible dye. These liposomes have several useful potential analytical applications, one of which is demonstrated. A simple plastic-backed nitrocellulose strip is the basis for an assay for detecting AFB1. Samples containing aflatoxin B1 are allowed to migrate by capillary action along the strip into a zone containing immobilized antibodies; then aflatoxin B1-tagged, dye-containing liposomes are allowed to migrate into the same area, filling any remaining antibody sites. The liposomes that bound to the antibody zone exhibit an intense purplish pink color whose optical density is inversely proportional to the aflatoxin concentration in the sample. The device is capable of detecting aflatoxin B1 at levels down to 20 ng and could serve as a rapid procedure for visual screening of agricultural and food samples for AFB1 or, with densitometry, as an inexpensive quantitative assay.