178876-82-9 Usage
Description
Methyl 6-amino-5-bromopyridine-2-carboxylate is an organic compound with the molecular formula C6H6BrNO2. It is a derivative of pyridine, featuring a bromine atom at the 5th position, an amino group at the 6th position, and a carboxylate group attached to a methyl group at the 2nd position. Methyl 6-amino-5-bromopyridine-2-carboxylate is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
Methyl 6-amino-5-bromopyridine-2-carboxylate is used as a key intermediate in the synthesis of aminopyridinamides. These aminopyridinamides are known as sodium channel modulators, which play a crucial role in various therapeutic applications.
As Sodium Channel Modulators:
Methyl 6-amino-5-bromopyridine-2-carboxylate is utilized in the development of aminopyridinamides that act as sodium channel modulators. These modulators are essential in the treatment of neurological disorders and conditions related to the abnormal functioning of sodium channels, such as epilepsy, chronic pain, and certain cardiac arrhythmias. By modulating the activity of sodium channels, these compounds can help regulate the flow of electrical signals in the nervous system, providing relief from symptoms and improving the quality of life for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 178876-82-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,8,7 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 178876-82:
(8*1)+(7*7)+(6*8)+(5*8)+(4*7)+(3*6)+(2*8)+(1*2)=209
209 % 10 = 9
So 178876-82-9 is a valid CAS Registry Number.
178876-82-9Relevant articles and documents
IMIDAZOPYRIDINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS
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Paragraph 0290, (2020/05/28)
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing co
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
Bagal, Sharan K.,Bungay, Peter J.,Denton, Stephen M.,Gibson, Karl R.,Glossop, Melanie S.,Hay, Tanya L.,Kemp, Mark I.,Lane, Charlotte A. L.,Lewis, Mark L.,Maw, Graham N.,Million, William A.,Payne, C. Elizabeth,Poinsard, Cedric,Rawson, David J.,Stammen, Blanda L.,Stevens, Edward B.,Thompson, Lisa R.
supporting information, p. 650 - 654 (2015/06/30)
Voltage-gated sodium channels, in particular Nav1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Nav1.8 modulator series to deliver subtype selective, state, and use-dependent chemical matter that is efficacious in preclinical models of neuropathic and inflammatory pain. (Chemical Presented).
ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME
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Page/Page column 40, (2011/07/06)
The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses t
