178903-65-6

Basic information

• Product Name: N-(2-methoxybenzyl)-1-(2-methoxyphenyl)methanamine
• Synonyms: benzenemethanamine, 2-methoxy-N-[(2-methoxyphenyl)methyl]-; Bis-(2-methoxy-benzyl)-amine
• CAS NO: 178903-65-6
• Molecular Formula: C₁₆H₁₉NO₂
• Molecular Weight: 257.3276
• Mol File: 178903-65-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 364.8°C at 760 mmHg
• Flash Point: 154.1°C
• Density: 1.073g/cm³
• Vapor Pressure: 1.64E-05mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: N-(2-methoxybenzyl)-1-(2-methoxyphenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxybenzyl)-1-(2-methoxyphenyl)methanamine(178903-65-6)
• EPA Substance Registry System: N-(2-methoxybenzyl)-1-(2-methoxyphenyl)methanamine(178903-65-6)

Safety Data

• Hazardous Substances Data: 178903-65-6(Hazardous Substances Data)

Upstream product

• 17745-81-2 1,2-bis(2-methoxybenzylidene)hydrazine 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 6609-56-9 2-methoxy-benzonitrile 
• 141-78-6 ethyl acetate 
• 135-02-4 ortho-anisaldehyde 
• 6850-57-3 2-methoxybenzylamine 

Relevant articles and documents

Switching Selectivity in Copper-Catalyzed Transfer Hydrogenation of Nitriles to Primary Amine-Boranes and Secondary Amines under Mild Conditions

A simple and efficient copper-catalyzed selective transfer hydrogenation of nitriles to primary amine-boranes and secondary amines with an oxazaborolidine-BH3 complex is reported. The selectivity control was achieved under mild conditions by switching the solvent and the copper catalysts. More than 30 primary amine-boranes and 40 secondary amines were synthesized via this strategy in high selectivity and yields of up to 95%. The strategy was applied to the synthesis of 15N labeled in 89% yield.

Conversion of Primary Amines to Symmetrical Secondary and Tertiary Amines using a Co-Rh Heterobimetallic Nanocatalyst

Symmetrical tertiary amines have been efficiently realized from amine and secondary amines via deaminated homocoupling with heterogeneous bimetallic Co2Rh2/C as catalyst (molar ratio Co:Rh=2:2). Unsymmetric secondary anilines were produced from the reaction of anilines with symmetric tertiary amines. The Co2Rh2/C catalyst exhibited very high catalytic activity towards a wide range of amines and could be conveniently recycled ten times without considerable leaching. (Figure presented.).

Rapid reduction of nitriles to primary amines with nickel boride at ambient temperature

Reduction of a variety of nitriles to their corresponding primary amines can be achieved with nickel boride generated in situ in dry ethanol at ambient temperature. The reductions are very rapid and chemoselective.