179024-59-0Relevant articles and documents
Method for preparing substituted [1,4]diazepino[6,7,1-hi]indol-4-ones
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Page column 16-17, (2008/06/13)
Method for the preparation of enantiomerically pure diazepino-indolone of formula which comprises the intramolecular cyclization of a product of formula where A, B, X1, X2, Z, Z1, Z2and R are as defined in the d
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles: Discovery of potent, selective phosphodiesterase type 4 inhibitors
Burnouf,Auclair,Avenel,Bertin,Bigot,Calvet,Chan,Durand,Fasquelle,Féru,Gilbertsen,Jacobelli,Kebsi,Lallier,Maignel,Martin,Milano,Ouagued,Pascal,Pruniaux,Puaud,Rocher,Terrasse,Wrigglesworth,Doherty
, p. 4850 - 4867 (2007/10/03)
The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submicromo