179057-16-0 Usage
Description
(4-(1H-pyrazol-3-yl)phenyl)Methanol, also known as 4-(1H-pyrazol-3-yl)benzyl alcohol, is a chemical compound characterized by its molecular formula C10H10N2O. It presents as a white to light yellow crystalline powder and is widely utilized in the fields of organic synthesis and medicinal chemistry. This versatile compound serves as a fundamental building block in the creation of an array of pharmaceuticals, agrochemicals, and other fine chemicals, making it a valuable asset in the development of novel biologically active compounds and pyrazole derivatives with diverse therapeutic applications.
Uses
Used in Pharmaceutical Industry:
(4-(1H-pyrazol-3-yl)phenyl)Methanol is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications. Its role in creating biologically active compounds makes it a crucial component in advancing pharmaceutical research and innovation.
Used in Agrochemical Synthesis:
In the agrochemical industry, (4-(1H-pyrazol-3-yl)phenyl)Methanol is employed as a key intermediate in the synthesis of agrochemicals, which are essential for enhancing crop protection and agricultural productivity.
Used in Organic Synthesis:
(4-(1H-pyrazol-3-yl)phenyl)Methanol is also utilized as a reagent in organic synthesis, where it aids in the production of a wide range of fine chemicals that find applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in the Synthesis of Pyrazole Derivatives:
(4-(1H-pyrazol-3-yl)phenyl)Methanol is used as an intermediate in the synthesis of various pyrazole derivatives, which possess a spectrum of biological activities. These derivatives hold potential for therapeutic applications, further highlighting the compound's significance in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 179057-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,0,5 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 179057-16:
(8*1)+(7*7)+(6*9)+(5*0)+(4*5)+(3*7)+(2*1)+(1*6)=160
160 % 10 = 0
So 179057-16-0 is a valid CAS Registry Number.
179057-16-0Relevant articles and documents
Inhibitors of acyl-coA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N- (heteroaryl-substituted benzyl)-N'-arylureas
Tanaka, Akira,Terasawa, Takeshi,Hagihara, Hiroyuki,Sakuma, Yuri,Ishibe, Noriko,Sawada, Masae,Takasugi, Hisashi,Tanaka, Hirokazu
, p. 2390 - 2410 (2007/10/03)
A series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylurea and related derivatives represented by 2 and 3 have been prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyltransferase in vitro and to lower plasma cholesterol levels in cholesterol-fed rats in vivo. Among these novel compounds, the type 3 series was superior. A pyrazol-3-yl group on the N-benzyl group of this trisubstituted urea (i.e. 3, Ar1 = pyrazol-3- yl) was identified as a heteroaromatic ring providing a good profile of biological activity. As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (At3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0.44 mg/kg administered by gavage in PEG400 vehicle). Moreover, a toxicological study revealed compound 3aq to be nontoxic to the adrenal glands of dogs when tested at a single dose of 10 mg/kg po.