179094-66-7Relevant articles and documents
Small peptides catalyze highly enantioselective direct aldol reactions of aldehydes with hydroxyacetone: Unprecedented regiocontrol in aqueous media
Tang, Zhuo,Yang, Zhi-Hua,Cun, Lin-Feng,Gong, Liu-Zhu,Mi, Ai-Qiao,Jiang, Yao-Zhong
, p. 2285 - 2287 (2004)
L-Proline-based small peptides have been developed as efficient catalysts for the asymmetric direct aldol reactions of hydroxyacetone with aldehydes. Chiral 1,4-diols 7, which are disfavored products in similar aldol reactions catalyzed by either aldolases or t-proline, were obtained in high yields and enantioselectivities of up to 96% ee with peptides 3 and 4 in aqueous media.