179411-72-4

Basic information

• Product Name: Carbamic acid, (3-amino-5-chlorophenyl)-, 1,1-dimethylethyl ester
• Synonyms: (3-amino-5-chlorophenyl)carbamic acid tert-butyl ester;3-amino-5-chlorophenylcarbamic acid, 1,1-dimethylethyl ester;(3-Amino-5-chloro-phenyl)-carbamic acid tert-butyl ester
• CAS NO: 179411-72-4
• Molecular Formula: C11H15ClN2O2
• Molecular Weight: 242.705
• Mol File: 179411-72-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (3-amino-5-chlorophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (3-amino-5-chlorophenyl)-, 1,1-dimethylethyl ester(179411-72-4)
• EPA Substance Registry System: Carbamic acid, (3-amino-5-chlorophenyl)-, 1,1-dimethylethyl ester(179411-72-4)

Safety Data

• Hazardous Substances Data: 179411-72-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 33786-89-9 5-chloro-1,3-benzenediamine 

Relevant articles and documents

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790Mmutant with improved pharmacokinetic properties

Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFRT790Minhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFRL858R/T790Mkinase and inhibited the proliferation of H1975?cells with IC50values of 2.0?nM and 40?nM, respectively. The compound dose-dependently induced reduction of the phosphorylation of EGFR and downstream activation of ERK in NCI[sbnd]H1975?cells. It also exhibited moderate plasma exposure after oral administration and an oral bioavailability value of 16%. Compound 9s may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer (NSCLC) patients.