179414-49-4

Basic information

• Product Name: 2-(BROMOMETHYL)-4-CHLOROBENZOTHIAZOLE
• Synonyms: 2-(BROMOMETHYL)-4-CHLOROBENZOTHIAZOLE
• CAS NO: 179414-49-4
• Molecular Formula: C8H5BrClNS
• Molecular Weight: 0
• Mol File: 179414-49-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(BROMOMETHYL)-4-CHLOROBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)-4-CHLOROBENZOTHIAZOLE(179414-49-4)
• EPA Substance Registry System: 2-(BROMOMETHYL)-4-CHLOROBENZOTHIAZOLE(179414-49-4)

Safety Data

• Hazardous Substances Data: 179414-49-4(Hazardous Substances Data)

Upstream product

• 40925-72-2 2-amino-3-chlorobenzenethiol 
• 19952-47-7 4-chlorobenzo[d]thiazol-2-amine 
• 3048-45-1 4-chloro-1,3-benzothiazole 
• 110704-20-6 4-chloro-2-(chloromethyl)benzo[d]thiazole 

Relevant articles and documents

Highly selective aldose reductase inhibitors. II. Optimization of the aryl part of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids

Accumulation of intracellular sorbitol, the product of glucose reduction catalyzed by aldose reductase (AR) [EC 1.1.1.21], is thought to be the main culprit in the development of diabetic complications. A series of 3- arylalkyl-2,4,5-trioxoimidazolidine-1-acetic acids was prepared and tested for inhibitory activities towards AR and aldehyde reductase (ALR) [EC 1.1.1.2]. These derivatives showed strong inhibitory activity against AR without markedly inhibiting ALR. In particular, the compounds with 3- nitrophenyl, 4-chloro-3-nitrophenyl, and chloro-substituted benzothiazolyl groups as the aryl part showed powerful AR-inhibitory activity. The chloro- substituted benzothiazolyl compound showed an AR selectivity of more than 5000 fold.