17950-66-2

Basic information

• Product Name: 2-Propyn-1-one, 1-(4-nitrophenyl)-3-(trimethylsilyl)-
• CAS NO: 17950-66-2
• Molecular Formula: C12H13NO3Si
• Molecular Weight: 247.326
• Mol File: 17950-66-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-one, 1-(4-nitrophenyl)-3-(trimethylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-one, 1-(4-nitrophenyl)-3-(trimethylsilyl)-(17950-66-2)
• EPA Substance Registry System: 2-Propyn-1-one, 1-(4-nitrophenyl)-3-(trimethylsilyl)-(17950-66-2)

Safety Data

• Hazardous Substances Data: 17950-66-2(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 1066-54-2 trimethylsilylacetylene 
• 81353-38-0 (trimethylsilylethynyl)tributyltin 
• 14630-40-1 Bis(trimethylsilyl)ethyne 

Downstream Products

• 100970-07-8 ethyl 2-methyl-6-(4-nitrophenyl)pyridine-3-carboxylate 
• 1253116-77-6 (1-benzyl-1H-1,2,3-triazol-4-yl)(4'-nitrophenyl)methanone 

Relevant articles and documents

Consecutive three- and four-component coupling-Bagley-Bohlmann-Rahtz syntheses of tri- and tetrasubstituted pyridines

The concatenation of the modified Sonogashira alkynone synthesis and the Bagley-Bohlmann-Rahtz pyridine synthesis gives novel consecutive three- and four-component coupling-Bagley-Bohlmann-Rahtz (cBBR) syntheses of tri- and tetrasubstituted pyridines in a one-pot fashion. With these processes 15 differently substituted 3-ethoxycarbonyl 2-methylpyridines can be readily obtained in modest to moderate yields.

One-pot three-step synthesis of 1,2,3-triazoles by copper-catalyzed cycloaddition of azides with alkynes formed by a Sonogashira cross-coupling and desilylation

A microwave-assisted, one-pot, three-step Sonogashira cross-coupling- desilylation-cycloaddition sequence was developed for the convenient preparation of 1,4-disubstituted 1,2,3-triazoles starting from a range of halides, acyl chlorides, ethynyltrimethyls

Palladium-Catalyzed Reactions of Acyl Chlorides with (1-Alkynyl)tributylstannanes. A Convenient Synthesis for 1-Alkynyl Ketones

Acyl chlorides couple with (1-alkynyl)tributylstannanes in the presence of catalytic amounts of palladium(II) or palladium(0) complexes to produce 1-alkynyl ketones in respectable yields.The couplings of isobutyryl, acetyl, benzoyl, and p-nitrobenzoyl chlorides with phenylethynyl-, (trimethylsilyl)ethynyl-, (carbomethoxy)ethynyl-, -1-propynyl>-, and (3,3-diethoxy-1-propynyl)tributylstannanes were investigated in the presence of tetrakis(triphenylphosphine)palladium(O), benzylchlorobis(triphenylphosphine)palladium(II), dichlorobis(triphenylphosphine)palladium(II), or phenyliodobis(triphenylphosphine)palladium(II).The reactions are highly selective in that only the alkynyl groups are transferred from the stannane.