17969-20-9 Usage
Description
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID, also known as Fenclozic Acid, is a chemical compound with potent anti-inflammatory, analgesic, and antipyretic properties. It is a human hepatotoxic drug, which means it can cause liver damage in humans.
Uses
Used in Pharmaceutical Industry:
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain and fever. However, its use is limited due to its hepatotoxic nature, and caution must be exercised when administering this compound to patients.
Originator
Fenclozic Acid,ZYF Pharm Chemical
Manufacturing Process
3.7 parts of 2-(4-chlorophenyl)-4-cyanomethylthiazole and 35 parts of 6 N
hydrochloric acid are heated under reflux for 2 hours. The solution is cooled
by the addition of ice and made alkaline to pH 8 by the addition of 30%
aqueous ammonia. The mixture is filtered to remove trace impurities, and an
excess of 40% sodium hydroxide solution is then added to the filtrate to cause
precipitation of a sodium salt, which is collected by filtration and crystallised
from water. There is thus obtained sodium 2-(4-chlorophenyl)thiazol-4-
ylacetate, M.P. 13°C (decomposition).This sodium salt is dissolved in hot water, and the solution is brought to pH 4
by the addition of acetic acid, which causes the precipitation of 2-(4-
chlorophenyl)thiazol-4-ylacetic acid. This is collected by filtration, washed with
water, and dried in vacuo over phosphorus pentoxide. It has an M.P. 155-
156°C (from ethyl acetate).
Therapeutic Function
Antiinflammatory, Analgesic, Antipyretic
Check Digit Verification of cas no
The CAS Registry Mumber 17969-20-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,9,6 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 17969-20:
(7*1)+(6*7)+(5*9)+(4*6)+(3*9)+(2*2)+(1*0)=149
149 % 10 = 9
So 17969-20-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H8ClNO2S/c12-8-3-1-7(2-4-8)11-13-9(6-16-11)5-10(14)15/h1-4,6H,5H2,(H,14,15)/p-1
17969-20-9Relevant articles and documents
Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds
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, (2008/06/13)
Compounds of the formula: RC(O)O-spacer-OC(O)R′, wherein (i) RC(O)— is the acyl residue of an NSAID or other pharmaceutically active agent bearing a carboxylic acid function, (ii) spacer is Cn alkyl, (iii) n is from 1 to 6, and (iv) R′ is substituted or unsubstituted heteroaryl or heterocycle, and pharmaceutical compositions thereof.
