179691-30-6Relevant articles and documents
A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation
Nguyen, Ha Phuong,Stewart, Sabrina,Kukwikila, Mikiembo N.,Jones, Sioned F?n,Offenbartl-Stiegert, Daniel,Mao, Shiqing,Balasubramanian, Shankar,Beck, Stephan,Howorka, Stefan
, p. 6620 - 6624 (2019)
Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as DNA methylation play a key role in this endeavour. DNA methylation can be controlled by genetic means. Yet there are few c
Nucleoside derivatives with photolabile protective groups
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, (2008/06/13)
The invention relates to nucleoside derivatives having photolabile protective groups of the general formula (I) STR1 in which R1 =H, NO2, CN, OCH3, halogen or alkyl or alkoxyalkyl having 1 to 4 C atoms R2 =H, OCH3 R3 =H, F, Cl, Br, NO2 R4 =H, halogen, OCH3, or an alkyl radical having 1 to 4 C atoms R5 =H or a usual functional group for preparing oligonucleotides R6 =H, OH, halogen or XR8, where X=O or S and R8 represents a protective group usual in nucleotide chemistry, B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl, or 5-amino-4-imidazolcarboxamid-3-yl, where in the case of B=adenine, cytosine or guanine, the primary amino function optionally exhibits a permanent protective group. These derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.
