17975-46-1

Basic information

• Product Name: 4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one
• Synonyms: 4-(4-Methoxybenzylidene)-3-methylisoxazol-5(4H)-one;4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one;4-(4-METHOXY-BENZYLIDENE)-3-METHYL-4H-ISOXAZOL-5-ONE
• CAS NO: 17975-46-1
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.22
• Mol File: 17975-46-1.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one(17975-46-1)
• EPA Substance Registry System: 4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one(17975-46-1)

Safety Data

• Hazardous Substances Data: 17975-46-1(Hazardous Substances Data)

Upstream product

• 3717-21-3 p-methoxyl benzaldoxime 
• 4341-76-8 Ethyl 2-butynoate 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 141-97-9 ethyl acetoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 16430-09-4 3-methyl-4-(1-phenylmethylidene)-5-isoxazolone 
• 1517-96-0 3-methyl-5-isoxazolone 
• 5470-11-1 hydroxylamine hydrochloride 
• 105-45-3 acetoacetic acid methyl ester 
• 5447-76-7 ethyl 3-oxobutanate oxime 

Downstream Products

• 622-73-1 4-methoxybenzaldehydephenylhydrazone 
• 95279-66-6 4-[1-(4-methoxy-phenyl)-2-phenyl-ethyl]-3-methyl-2H-isoxazol-5-one 
• 94005-25-1 4-(4-methoxy-benzhydryl)-3-methyl-2H-isoxazol-5-one 
• 35113-38-3 [(4-methoxy-phenyl)-(3-methyl-5-oxo-2,5-dihydro-isoxazol-4-yl)-methyl]-phosphonic acid dimethyl ester 
• 95279-67-7 4-(4-methoxy-4'-methyl-benzhydryl)-3-methyl-2H-isoxazol-5-one 
• 128156-33-2 4-(4-Methoxy-benzyl)-3-methyl-2H-isoxazol-5-one 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 128156-50-3 4,4'-Bis-(4-methoxy-benzyl)-3,3'-dimethyl-4H,4'H-[4,4']biisoxazolyl-5,5'-dione 
• 1569091-58-2 C₂₈H₂₃N₃O₄S 

Relevant articles and documents

Fruit Extract of Averrhoa bilimbi: A Green Neoteric Micellar Medium for Isoxazole and Biginelli-Like Synthesis

A transition metal/ligand/additive/promoter-free synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones and the Biginelli-like synthesis is carried out in a natural acidic medium of Averrhoa bilimbi extract (ABE) with cleaner and facile approach smenti

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

Cu/TCH-pr&at;SBA-15 nano-composite: A new organometallic catalyst for facile three-component synthesis of 4-arylidene-isoxazolidinones

A copper complex supported on SBA-15 nanoparticles (Cu/TCH-pr&at;SBA-15) was synthesized by the post-synthesis modification of nano-mesoporous silica with 3-chloropropyltriethoxysilane (CPTES) and thiocarbohydrazide (TCH) and subsequent metal-ligand coord