179895-47-7

Basic information

• Product Name: LG 120747
• CAS NO: 179895-47-7
• Molecular Weight: 419.926
• Mol File: 179895-47-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: LG 120747(CAS DataBase Reference)
• NIST Chemistry Reference: LG 120747(179895-47-7)
• EPA Substance Registry System: LG 120747(179895-47-7)

Safety Data

• Hazardous Substances Data: 179895-47-7(Hazardous Substances Data)

Upstream product

• 179898-09-0 methyl (5'-fluoro-2'-methoxy-4-nitro-2-biphenyl)carboxylate 
• 179898-10-3 5'-fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid 
• 6942-36-5 methyl 2-bromo-5-nitrobenzoate 
• 179895-41-1 9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-aza-chrysen-5-one 
• 179898-11-4 2-Fluoro-8-nitro-benzo[c]chromen-6-one 
• 54932-72-8 2-chloro-5-bromotoluene 

Relevant articles and documents

Preparation, resolution, and biological evaluation of 5-aryl-1,2- dihydro-5H-chromeno[3,4-f]quinolines: Potent, orally active, nonsteroidal progesterone receptor agonists

Two potent nonsteroidal progestins from the 5-aryl-1,2-dihydro-5H- chromeno[3,4-f]quinoline class (LG120746 and LG120747) were selected for scale-up, resolution, and biological evaluation of the purified enantiomers. For each quinoline, the levorotatory enantiomer was determined to be the more potent agonist of the human progesterone receptor isoform B (hPR-B) (EC50 50 200 nM). In two in vivo rodent models of progestational activity, a pregnancy maintenance assay and a uterine wet weight assay, the two eutomers displayed potent progesterone-like effects. In a third model for progestational activity, the mammary end bud assay, these compounds were significantly less active. These studies demonstrate that certain members of this class of selective progesterone receptor modulators display encouraging and potentially useful tissue-selective progestational effects.