17990-70-4

Basic information

• Product Name: 3-(2-aminobenzylidene)-1,3-dihydro-2H-indol-2-one
• Synonyms: 3-(2-aminobenzylidene)-1,3-dihydro-2H-indol-2-one
• CAS NO: 17990-70-4
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.26858
• Mol File: 17990-70-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2-aminobenzylidene)-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-aminobenzylidene)-1,3-dihydro-2H-indol-2-one(17990-70-4)
• EPA Substance Registry System: 3-(2-aminobenzylidene)-1,3-dihydro-2H-indol-2-one(17990-70-4)

Safety Data

• Hazardous Substances Data: 17990-70-4(Hazardous Substances Data)

Upstream product

• 59-48-3 2-oxoindole 
• 55857-35-7 (E)-N-(2-aminobenzylidene)-4-methylaniline 
• 19470-74-7 3-((E)-2-nitro-benzylidene)-indolin-2-one 
• 552-89-6 2-nitro-benzaldehyde 
• 529-23-7 o-aminobenzaldehyde 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents

A series of novel polycyclic spiro-fused carbocyclicoxindoles were synthesized and investigated for their in?vitro antiproliferative activities against nine human cancer cell lines. Five compounds (10i, 10l, 10n, 10p, and 10r) demonstrated anticancer activities against A2780s cells with IC50values of less than 30?μM. In particular, compound 10i showed anticancer activities against seven cancer cell lines and stronger activities than cisplatin in A2780s, A2780T, CT26, and HCT116?cells. Further studies illustrated that compound 10i arrested cell cycle in G1 phase and induced apoptosis of HCT116?cells. This compound also effectively increased the protein levels of cleaved caspase-3, p53, and MDM2. Molecular docking results revealed that compound 10i could bind well to the p53-binding site on MDM2, indicating that it might work by blocking the MDM2-p53 interactions.