179928-10-0

Basic information

• Product Name: 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine
• Synonyms: 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine
• CAS NO: 179928-10-0
• Molecular Weight: 351.224
• Mol File: 179928-10-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine(179928-10-0)
• EPA Substance Registry System: 6-bromo-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine(179928-10-0)

Safety Data

• Hazardous Substances Data: 179928-10-0(Hazardous Substances Data)

Upstream product

• 931-33-9 4-bromopyrrole-2-carboxaldehyde 
• 5697-44-9 p-tolylsulfonylmethyl isocyanide 
• 1003-29-8 2-pyrrole aldehyde 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 

Downstream Products

• 5910-05-4 methyl 2-formyl-4-pyrrolcarboxylate 
• 179928-19-9 6-methylpyrrolo[1,2-c]pyrimidine 
• 179928-11-1 6-methyl-3-[(4-methylphenyl)sulfonyl]pyrrolo[1,2-c]pyrimidine 

Relevant articles and documents

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists

Monocyclic and bicyclic ring systems were investigated as the "core" section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in both the monocyclic and bicyclic cores. Residence times for the monocyclic compounds were very short. Some of the bicyclic cores displayed better residence times. A methyl group in the northern part of the core, between the head and tail was a necessary requirement for the beginnings of long residence times. Variations of the tail substitution maximised potencies and residence times.

Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives

An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]- pyrimidines with sodium amalgam is described.