180031-78-1Relevant articles and documents
4-furfurylthiopentanone-2 preparation method
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Paragraph 0039-0040; 0047-0050; 0057-0060; 0067-0070, (2019/11/04)
The invention belongs to the technical field of fine chemistry, and provides a 4-furfurylthiopentanone-2 preparation method, which specifically comprises: adding a raw material chloroacetone to a toluene solution of triphenylphosphine or to triethyl phosphite, and carrying out a heating reflux reaction to obtain a phosphorus salt; dissolving the obtained phosphorus salt in an organic solvent, adding a strong alkali, stirring for 2-3 h, and obtaining phosphorus ylide after completing a reaction; adding the phosphorus ylide to an acetaldehyde aqueous solution or paraldehyde, and stirring until the reaction is completed to obtain 3-pentene-2-ketone; adding piperidine to the 3-pentene-2-ketone, adding a dichloromethane solution of furfuryl mercaptan in a dropwise manner, and controlling the temperature of the system during the adding at 35-40 DEG C; and after the adding, stirring until the reaction is completed so as to obtain the product 4-furfurylthiopentanone-2. According to the present invention, with the method, the problems of high risk, high cost and being unsuitable for industrial production of the 4-furfurylthiopentanone-2 synthesis route in the prior art are solved.