1800345-36-1

Basic information

• Product Name: (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol
• Synonyms: (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol;(R)-phenyl(tetrahydro-2H-pyran-4-yl)methanol;(αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol,99%e.e.;EOS-61897
• CAS NO: 1800345-36-1
• Molecular Formula: C12H16O2
• Molecular Weight: 192.26
• Mol File: 1800345-36-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol(1800345-36-1)
• EPA Substance Registry System: (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol(1800345-36-1)

Safety Data

• Hazardous Substances Data: 1800345-36-1(Hazardous Substances Data)

Usage

General Description

(αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol is a chemical compound with the molecular formula C15H18O2. It is a chiral molecule with a specific spatial arrangement of its atoms. (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol is a member of the pyranol family, which are cyclic compounds containing a six-membered ring with five carbon atoms and one oxygen atom. (αR)-Tetrahydro-α-phenyl-2H-pyran-4-methanol is used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceutical compounds and biologically active molecules. Its specific stereoisomeric structure and functional groups make it an important intermediate in the production of drugs and other bioactive substances.

Upstream product

• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 639468-72-7 phenyl(tetrahydro-2H-pyran-4-yl)methanone 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 101765-10-0 tetrahydro-4-(methoxymethylene)-2H-pyran 
• 156353-01-4 N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 100-59-4 phenylmagnesium chloride 
• 3174-74-1 dihydropyran 
• 100-52-7 benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 216087-92-2 rac-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol 

Downstream Products

• 1800340-40-2 (-)-(S)-2-[3-(dimethyl-1H-1, 2,3-triazo1-5-yl)-5-[oxan-4-yl(phenyl)-methyl]-5H-pyrido [3,2-b] indol-7-yl]propan-2-ol 

Relevant articles and documents

Development of BET inhibitors as potential treatments for cancer: A search for structural diversity

We describe our efforts to identify structurally diverse leads in the triazole-containing N1-carboline series of bromodomain and extra-terminal inhibitors. Replacement of the N5 “cap” phenyl moiety with various heteroaryls, coupled with additional modifications to the carboline core, provided analogs with similar potency, improved pharmacokinetic properties, and increased solubility compared to our backup lead, BMS-986225 (2). Rapid SAR exploration was enabled by a convergent, synthetic route. These efforts provided a potent BET inhibitor, 3-fluoropyridyl 12, that demonstrated robust efficacy in a multiple myeloma mouse tumor model at 1 mg/kg.

SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF

Provided herein are 2-amino-pyrazolyl-[ 1,2,4]triazolo [1,5a]pyridine derivatives. Such compounds are useful, for example, for the treatment and/or prevention of neurodegenerative diseases or disorders such as ophthalmological neurodegenerative disorders. This disclosure also features compositions containing the same as well as methods of using and making the same.

TRICYCLIC COMPOUND FOR BROMODOMAIN-CONTAINING PROTEIN INHIBITOR AND PREPARATION, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF

The present applicationpresent application relates to a compound represented by Formula (III) or a pharmaceutically acceptable salt, solvent compound, active metabolite, crystal polymorph, ester, isomer, or prodrug thereof. The application further provides a pharmaceutical composition comprising the compound represented by Formula (III) and a use thereof for preparing a bromodomain inhibitor for preventing or treating various diseases, such as inflammation and cancer, related to the bromodomain.