180057-14-1

Basic information

• Product Name: 9-o-Tolyl-thieno[2,3-c][1,5]naphthyridine 5-oxide
• Synonyms: 9-o-Tolyl-thieno[2,3-c][1,5]naphthyridine 5-oxide
• CAS NO: 180057-14-1
• Molecular Weight: 292.361
• Mol File: 180057-14-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-o-Tolyl-thieno[2,3-c][1,5]naphthyridine 5-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 9-o-Tolyl-thieno[2,3-c][1,5]naphthyridine 5-oxide(180057-14-1)
• EPA Substance Registry System: 9-o-Tolyl-thieno[2,3-c][1,5]naphthyridine 5-oxide(180057-14-1)

Safety Data

• Hazardous Substances Data: 180057-14-1(Hazardous Substances Data)

Upstream product

• 154418-91-4 1-bromothieno-<2,3-c>-1,5-naphthyridine 
• 17113-82-5 1-methyl-2-(trimethylstannyl)benzene 
• 180057-13-0 9-o-Tolyl-thieno[2,3-c][1,5]naphthyridine 

Downstream Products

• 180057-12-9 6-Chloro-9-o-tolyl-thieno[2,3-c][1,5]naphthyridine 

Relevant articles and documents

4-Substituted 1-(2-methylphenyl)thieno[2,3-c]-1,5-naphthyridines as possible reversible inhibitors of gastric M+,K+-ATPase

Seven 1-(2-methylphenyl)thieno[2,3-c]-1,5-naphthyridines substituted in the 4-position with different amino-containing groups have been prepared. The reaction route to these compounds consisted of a palladium(0)-catalyzed cross-coupling between 1-bromothieno[2,3-c]-1,5-naphthyridine and 2-methyl-1-trimethylstannylbenzene, then oxidation of the 5-nitrogen, followed by treatment with thionyl chloride to give the 4-chloro derivative. The compounds obtained after nucleophilic substitution were tested with regard to their effects on H+,K+-ATPase activity and on acid formation in gastric glands. However, the inhibitory potency in vitro of the substituted naphthyridines was not high enough to be of interest from a pharmacological point of view.