180081-24-7

Basic information

• Product Name: Carbamic acid, [(3-amino-4-methoxyphenyl)methyl]-, 1,1-dimethylethyl ester
• CAS NO: 180081-24-7
• Molecular Formula: C13H20N2O3
• Molecular Weight: 252.313
• Mol File: 180081-24-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(3-amino-4-methoxyphenyl)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3-amino-4-methoxyphenyl)methyl]-, 1,1-dimethylethyl ester(180081-24-7)
• EPA Substance Registry System: Carbamic acid, [(3-amino-4-methoxyphenyl)methyl]-, 1,1-dimethylethyl ester(180081-24-7)

Safety Data

• Hazardous Substances Data: 180081-24-7(Hazardous Substances Data)

Upstream product

• 17481-27-5 3-amino-4-methoxybenzamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 60518-02-7 5-(aminomethyl)-2-methoxyaniline 

Relevant articles and documents

Synthesis of potent and selective 2-azepanone inhibitors of human tryptase

The serine protease tryptase has been associated with a broad range of allergic and inflammatory diseases and, in particular, has been implicated as a critical mediator of asthma. The inhibition of tryptase therefore has the potential to be a valuable therapy for asthma. The synthesis, employing solution phase parallel methods, and SAR of a series of novel 2-azepanone tryptase inhibitors are presented. A member of this series, 8t, was identified as a potent inhibitor of human tryptase (IC50=38 nM) with selectivity ≤330-fold versus related serine proteases (trypsin, plasmin, uPA, tPA, APC, alpha-thrombin, and FXa).