180081-30-5

Basic information

• Product Name: Carbamic acid, [(3-amino-4-chlorophenyl)methyl]-, 1,1-dimethylethyl ester
• CAS NO: 180081-30-5
• Molecular Formula: C12H17ClN2O2
• Molecular Weight: 256.732
• Mol File: 180081-30-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(3-amino-4-chlorophenyl)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3-amino-4-chlorophenyl)methyl]-, 1,1-dimethylethyl ester(180081-30-5)
• EPA Substance Registry System: Carbamic acid, [(3-amino-4-chlorophenyl)methyl]-, 1,1-dimethylethyl ester(180081-30-5)

Safety Data

• Hazardous Substances Data: 180081-30-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 94568-51-1 3-amino-4-chlorobenzylamine 
• 180081-29-2 N-(4-chloro-3-nitrophenylmethyl)carbamic acid t-butyl ester 
• 19694-10-1 4-chloro-3-amino-benzoic acid amide 

Downstream Products

• 1242268-43-4 tert-butyl 4-chloro-3-isothiocyanatobenzylcarbamate 
• 1380920-95-5 tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate 
• 1380920-96-6 4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino]benzylamine 
• 1380921-02-7 N-{4-chloro-3-[5-chloro-6-(3-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-carbamic acid tert-butyl ester 
• 1380921-03-8 4-chloro-3-[5-chloro-6-(3-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzylamine 
• 1380919-17-4 N-{4-chloro-3-[5-chloro-6-(3-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1380921-06-1 {3-[6-(5-aza-spiro[2.4]hept-5-yl)-5-chloro-1H-benzimidazol-2-ylamino]-4-chloro-benzyl}-carbamic acid tert-butyl ester 
• 1380921-13-0 {4-chloro-3-[5-chloro-6-(2-dimethylaminomethyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-carbamic acid tert-butyl ester 
• 916051-33-7 4-{[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]amino}-4-oxobutanoic acid 
• 916051-31-5 N₁-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]-N₂,N₂-dimethylglycinamide 
• 916052-24-9 N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]methanesulfonamide 
• 916051-56-4 methyl [(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]carbamate 
• 916051-29-1 N-[(4-chloro-3-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methyl]urea 
• 916050-72-1 (5Z)-2-{[5-(aminomethyl)-2-chlorophenyl]amino}-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one 

Relevant articles and documents

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.

3H-IMIDAZO [4, 5 -C] PYRIDINE- 6 -CARBOXAMIDES AS ANTI- INFLAMMATORY AGENTS

The present invention relates to compounds of general formula (I) in which A, L, M, Q2, Q3, Q4, R1, R5, Ra, Rb, Rc, W, X, Y, Z1, Z2, Z3 are defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

Aniline derivatives possessing an inhibitory effect of nitric oxide synthase

Compounds represented by the general formula (1): ? (where R1is SR6or NR7R8, where R6is typically an alkyl group having 1-6 carbon atoms, R7is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2and R3are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3and Y4which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases.