1801-62-3

Basic information

• Product Name: 1,3-DIMETHYL-2-THIOHYDANTOIN
• Synonyms: 1,3-DIMETHYL-2-THIOHYDANTOIN;N,N'-DIMETHYLTHIOHYDANTOIN;Dimethylthiohydantoin;N,N'-Dimethylthiohydantoine;1,3-DIMETHYL-2-THIOHYDANTOIN 98+%;1,3-Dimethyl-2-thioxoimidazolidin-4-one
• CAS NO: 1801-62-3
• Molecular Formula: C₅H₈N₂OS
• Molecular Weight: 144.19
• Mol File: 1801-62-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 93°C
• Appearance: Pale orange/Solid
• CAS DataBase Reference: 1,3-DIMETHYL-2-THIOHYDANTOIN(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIMETHYL-2-THIOHYDANTOIN(1801-62-3)
• EPA Substance Registry System: 1,3-DIMETHYL-2-THIOHYDANTOIN(1801-62-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1801-62-3(Hazardous Substances Data)

Usage

General Description

1,3-Dimethyl-2-thiohydantoin is a chemical compound used primarily in the field of analytical chemistry. This chemical is a derivative of hydantoin, which is known for its various biological activities. It possesses a unique chemical structure, consisting of a thiohydantoin moiety with two additional methyl groups. It is often used in research as a reactant or intermediate compound, both due to its reactivity and compatibility with various functional groups. It is vital to handle this reagent with care due to its potential hazards, including skin and eye irritation upon direct contact. Researchers continue to study 1,3-Dimethyl-2-thiohydantoin to determine its potential applications in pharmaceuticals.

Upstream product

• 74404-63-0 1-cyanomethyl-1,3-dimethylthiourea 
• 556-61-6 methyl thioisocyanate 
• 5616-32-0 (methylamino)acetonitrile 
• 7647-01-0 hydrogenchloride 
• 107-97-1 sarcosine 
• 13515-93-0 N-methylglycine methyl ester hydrochloride 
• 67-56-1 methanol 
• 861552-34-3 C₅H₁₀N₂O₂S 
• 79-19-6 thiosemicarbazide 
• 1937-19-5 1-aminoguanidine hydrochloride 

Downstream Products

• 54118-10-4 5-(1,3-dimethyl-5-oxo-2-thioxo-imidazolidin-4-ylidene)-3-(3-ethyl-3H-benzothiazol-2-ylidenemethyl)-cyclohex-3-enecarboxylic acid amide 
• 2445-60-5 1,3-dimethyl-5-[2-(1-methyl-pyrrolidin-2-ylidene)-ethylidene]-2-thioxo-imidazolidin-4-one 
• 106164-71-0 5-[(1,3-dimethyl-pyrrolidin-2-yliden)-ethylidene]-1,3-dimethyl-2-thioxo-imidazolidin-4-one 
• 354119-54-3 5-((E)-3,4-methylenedioxybenzylidene)-1,3-dimethyl-2-thiohydantoin 
• 354119-53-2 5-((E)-3,4,5-trimethoxybenzylidene)-1,3-dimethyl-2-thiohydantoin 
• 473739-41-2 1,3-dimethyl-5-[(E)-1-phenylmethylidene]-2-thioxoimidazolidin-4-one 

Relevant articles and documents

Novel rhodanine derivatives induce growth inhibition followed by apoptosis

We have designed and synthesized three novel compounds, 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4- oxazolidinedione (ITO-1), and 5-benzilidene-3-ethyl rhodanine (BTR-1), and have tested their chemotherapeutic properties. Our results showed that all three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC50 value of BTR-1 was estimated to be a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.

Oxidative desulfurization of azole-2-thiones with benzoyl peroxide: Syntheses of ionic liquids and other azolium salts

1-Alkyl-3-methylimidazole-2-thiones were prepared from amino esters in one pot and converted to inherently halide-free 1-alkyl-3-methylimidazolium benzoates by oxidation with benzoyl peroxide followed by a novel anion exchange. Also reported are the outcomes of exchanges with other anions, acidifications of the imidazolium benzoates to other salts, and extension of the method to the syntheses of 1,3-diphenylimidazolium and 3-methyl- and -butylthiazolium salts. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.