180145-62-4

Basic information

• Product Name: 2-<(E)-cinnamylthio>-6-methyl-4(3H)-pyrimidinone
• Synonyms: 2-<(E)-cinnamylthio>-6-methyl-4(3H)-pyrimidinone
• CAS NO: 180145-62-4
• Molecular Weight: 258.344
• Mol File: 180145-62-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-<(E)-cinnamylthio>-6-methyl-4(3H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<(E)-cinnamylthio>-6-methyl-4(3H)-pyrimidinone(180145-62-4)
• EPA Substance Registry System: 2-<(E)-cinnamylthio>-6-methyl-4(3H)-pyrimidinone(180145-62-4)

Safety Data

• Hazardous Substances Data: 180145-62-4(Hazardous Substances Data)

Upstream product

• 4392-24-9 Cinnamyl bromide 
• 56-04-2 6-methyl-2-thiouracil 
• 106625-69-8 ethyl (E)-3-phenyl-2-propenyl carbonate 
• 21040-45-9 Cinnamyl acetate 

Downstream Products

• 180145-60-2 3-cinnamyl-6-methyl-2-thiouracil 

Relevant articles and documents

Palladium(0)-catalysed allylation of uracils and thiouracils. Influence of the solvent on the regioselectivity of the allylation

Uracil and 5-substituted uracils are monoallylated at N-1 in H2O- CH3CN with the catalytic systemPd(OAc)2/P(C6H4-m -SO3Na)3 (or tppts) although performing the reaction in H2O/THF with the system Pd2(dba)3/dppb leads to diallylations at N-1 + N-3.2-Thiouracil, 5-methyl-2-thiouracil (2- thiothymine) and 6-methyl-2-thiouracil are monoallylated at sulfur in H2O/CH3CN with the catalytic system Pd(OAc)2/P(C6H4-m-SO3Na)3 (or tppts). Performing the reactions in H2O/THF with the system Pd2(dba)3/dppb leads to diallylations at N-1 + N-3 of 2-thiouracil and 2-thiothymine whereas 6-methyl-2-thiouracil is diallylated at S + N-3.