180146-29-6Relevant articles and documents
2,6-Quinolinyl derivatives as potent VLA-4 antagonists
Lassoie, Marie-Agnes,Broeders, Fabienne,Collart, Philippe,Defrere, Laurent,de Laveleye-Defais, Francoise,Demaude, Thierry,Gassama, Abdoulaye,Guillaumet, Gerald,Hayez, Jean-Claude,Kiss, Laszlo,Knerr, Laurent,Nicolas, Jean-Marie,Norsikian, Stephanie,Quere, Luc,Routier, Sylvain,Verbois, Valerie,Provins, Laurent
, p. 142 - 146 (2007/10/03)
A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.
Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
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, (2008/06/13)
Compounds represented by the general formula (1): ? (where R1is SR6or NR7R8, where R6is typically an alkyl group having 1-6 carbon atoms, R7is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2and R3are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3and Y4which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases.
