180193-72-0

Basic information

• Product Name: Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)-
• CAS NO: 180193-72-0
• Molecular Formula: C26H30NO4P
• Molecular Weight: 451.502
• Mol File: 180193-72-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)-(180193-72-0)
• EPA Substance Registry System: Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)-(180193-72-0)

Safety Data

• Hazardous Substances Data: 180193-72-0(Hazardous Substances Data)

Usage

General Description

Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)- is a chiral compound with potential uses in medicinal chemistry and drug development. It is a dimethyl ester of phosphonic acid, containing a chiral center and a complex substituent with phenyl and amino groups. Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)- has the potential to be used as a pharmaceutical intermediate or as a building block in the synthesis of bioactive molecules. Its pharmacological properties and potential therapeutic applications are areas of active research and development in the pharmaceutical industry.

Upstream product

• 63-91-2 L-phenylalanine 
• 111138-83-1 N,N-dibenzyl-L-phenylalanine benzyl ester 
• 756-79-6 dimethyl methane phosphonate 

Downstream Products

• 198635-28-8 4-((E)-(S)-4-Dibenzylamino-3-oxo-5-phenyl-pent-1-enyl)-benzaldehyde 
• 198635-30-2 (E)-(S)-4-Dibenzylamino-1-naphthalen-1-yl-5-phenyl-pent-1-en-3-one 
• 198635-29-9 (E)-(S)-4-Dibenzylamino-1-(4-methoxy-phenyl)-5-phenyl-pent-1-en-3-one 
• 180193-77-5 (2R,5S)-5-Dibenzylamino-4-oxo-2,6-diphenyl-hexanoic acid butyl ester 
• 180193-80-0 (2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester 
• 198635-31-3 (E)-(S)-4-Dibenzylamino-1,5-diphenyl-pent-1-en-3-one 
• 750638-95-0 (E)-(S)-5-Dibenzylamino-4-oxo-6-phenyl-hex-2-enoic acid butyl ester 

Relevant articles and documents

Diastereoselective reduction of β-ketophosphonates derived from amino acids. A new entry to enantiopure β-hydroxy-γ-aminophosphonate derivatives

The reduction of γ-N,N-dibenzylamino-β-ketophosphonates 4 derived from readily available (S)-tribenzylated amino acids was achieved with catecholborane at -20°C affording γ-amino-β-hydroxyphosphonates 5 in high diastereoselectivity and good chemical yield. These reactions provide a new entry to enantiomerically pure γ-amino-β-hydroxyphosphonates.

Remote asymmetric induction in organocopper conjugate additions to 3-ketoacrylates

Remote asymmetric induction has been achieved in the conjugate addition of organocopper reagents to a novel 3-ketoacrylate system, 1. Conjugate additions proceed in moderate to good yield and with high regio-and stereoselectivity in the presence of diethylaluminum chloride. Copyright