180283-48-1

Basic information

• Product Name: 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde
• Synonyms: 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde
• CAS NO: 180283-48-1
• Molecular Weight: 277.344
• Mol File: 180283-48-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde(180283-48-1)
• EPA Substance Registry System: 3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde(180283-48-1)

Safety Data

• Hazardous Substances Data: 180283-48-1(Hazardous Substances Data)

Upstream product

• 19713-89-4 3,4-dimethylpyrrole-2-carboxaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 180283-67-4 [3,4-Dimethyl-1-(toluene-4-sulfonyl)-1H-pyrrol-2-yl]-methanol 

Relevant articles and documents

Synthesis of N-protected 2-hydroxymethylpyrroles and transformation into acyclic oligomers

The synthesis of N-tosylated and N-Boc-protected 2-hydroxymethyl-pyrroles 2a-c and 3a-d and their transformation into di- and tripyrroles 18, 20a and 20b as well as the preparation of the vinyl- and ethynylpyrroles 13a, 13b and 15 is described. The pyrrole-2-carboxylic acid ethyl esters 7a and b and the pyrrole-2-carbaldehydes 4a-d were transformed into their N-protected derivatives 5a, 5b, 6a-d, 8a and 8b in 69-97% yield and reduced to give the corresponding hydroxymethylpyrroles 2a-c and 3a-d in 79-96% yield; treatment of 2b with 17, 19a and 19b in 0.5% hydrochloric acid gives the dipyrrole 18 and the tripyrroles 20a and 20b in 20-28% yield.