180293-53-2

Basic information

• Product Name: methyl 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionate
• CAS NO: 180293-53-2
• Molecular Weight: 238.302
• Mol File: 180293-53-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionate(180293-53-2)
• EPA Substance Registry System: methyl 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionate(180293-53-2)

Safety Data

• Hazardous Substances Data: 180293-53-2(Hazardous Substances Data)

Upstream product

• 180293-52-1 2-fluoro-2-(4-isobutylphenyl)propanenitrile 
• 74590-67-3 ethyl 2-fluoro-2-(4-isobutylphenyl)propanoate 
• 60473-29-2 ethyl 2-(4-isobutylphenyl)-2-hydroxypropanoate 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 2051-99-2 1-bromo-4-isobutylbenzene 
• 15687-27-1 ibuprofen 
• 101970-32-5 methyl 2-hydroxy-2-(4-isobutylphenyl)propionate 
• 61566-34-5 (+/-)-ibuprofen methyl ester 
• 186581-53-3 diazomethane 
• 180293-49-6 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid 

Downstream Products

• 863224-94-6 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2S)-2-fluoro-2-[4-(2-methylpropyl)phenyl]propionate 
• 863224-93-5 (1R,2R,3R,6S)-4-hydroxy-4,7,7-trimethylbicyclo[4.1.0]hept-3-yl (2R)-2-fluoro-2-[4-(2-methylpropyl)phenyl]propionate 
• 180293-49-6 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid 

Relevant articles and documents

Inhibition of human α-methylacyl CoA racemase (AMACR): A target for prostate cancer

The enzyme α-methylacyl CoA racemase (AMACR) is involved in the metabolism of branched-chain fatty acids and has been identified as a promising therapeutic target for prostate cancer. By using the recently available human AMACR from HEK293 kidney cell cultures, we tested a series of new rationally designed inhibitors to determine the structural requirements in the acyl component. An N-methylthiocarbamate (Ki=98nM), designed to mimic the proposed enzyme-bound enolate, was found to be the most potent AMACR inhibitor reported to date. Enolate mimicry: A range of inhibitors were designed and synthesized to determine the structural requirements for inhibition of the prostate cancer target racemase AMACR using the recently available human enzyme from HEK293 kidney cell cultures. An N-methylthiocarbamate (Ki=98nM), designed to mimic the proposed enzyme-bound enolate, is the most potent AMACR inhibitor reported to date.

Synthesis and optical resolution of 2-aryl-2-fluoropropionic acids, fluorinated analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)

We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.

α-Fluoro analogues of inflammation inhibiting α-arylpropionic acids

2-Aryl-2-fluoropropionic acids were prepared by treatment of either ethyl α-hydroxy-carboxylates or cyanohydrin O-silyl ethers with diethylaminosulfur trifluoride and subsequent hydrolysis. The methyl ester of 2-fluoro-2-(4- isobutylphenyl)propionic acid