180534-23-0Relevant articles and documents
Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals
Seward, Eileen M,Carlson, Emma,Harrison, Timothy,Haworth, Karen E.,Herbert, Richard,Kelleher, Fintan J.,Kurtz, Marc M.,Moseley, Jonathan,Owen, Simon N.,Owens, Andrew P.,Sadowski, Sharon J.,Swain, Christopher J.,Williams, Brian J.
, p. 2515 - 2518 (2007/10/03)
A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.