180570-71-2

Basic information

• Product Name: N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-BETA-TRITYL-D-ASPARAGINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-BETA-TRITYL-D-ASPARAGINE;FMOC-D-ASN(TRT);FMOC-D-ASN(TRT)-OH;FMOC-D-ASPARAGINE(TRITYL);FMOC-D-ASPARAGINE(TRT);FMOC-N-GAMMA-TRITYL-D-ASPARAGINE;FMOC-N-BETA-TRITYL-D-ASPARAGINE
• CAS NO: 180570-71-2
• Molecular Formula: C38H32N2O5
• Molecular Weight: 596.67
• Product Categories: Amino Acids;Asparagine [Asn, N];Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 180570-71-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 211-216°C
• Boiling Point: 831.397 °C at 760 mmHg
• Flash Point: 456.613 °C
• Appearance: /
• Density: 1.29 g/cm³
• Refractive Index: 1.655
• Storage Temp.: -20°C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Sparingly)
• PKA: 3.79±0.10(Predicted)
• Stability: Acid Sensitive
• CAS DataBase Reference: N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine(180570-71-2)
• EPA Substance Registry System: N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine(180570-71-2)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 180570-71-2(Hazardous Substances Data)

Usage

Description

N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine, also known as Fmoc-d-asn(trt)-oh, is a synthetic amino acid building block that plays a crucial role in peptide synthesis. As a derivative of D-asparagine, it is characterized by the presence of a 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group and a trityl (Trt) group. This white powder is highly valued in the pharmaceutical and biotechnology industries due to its ability to facilitate the fast and reliable synthesis of peptides, which is essential in the rapidly growing peptide drug market.

Uses

Used in Pharmaceutical Industry:
N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine is used as a key building block in the synthesis of peptides for various pharmaceutical applications. Its role in peptide synthesis is vital for the development of new drugs and therapeutic agents, as it allows for the efficient and accurate assembly of peptide sequences.
Used in Biotechnology Industry:
In the biotechnology sector, N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine serves as an essential component in the creation of peptide-based bioactive molecules. These molecules have potential applications in research, diagnostics, and therapeutics, making this compound a valuable asset in advancing biotechnological innovations.
Used in Peptide Drug Development:
N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine is utilized as a crucial intermediate in the development of peptide drugs. Its presence in the synthesis process ensures the protection of the peptide's amino group, which is vital for maintaining the integrity and functionality of the final peptide product.
Used in Academic Research:
N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine is also widely used in academic research settings, where it contributes to the study of peptide chemistry, synthesis techniques, and the exploration of new peptide-based therapeutic agents. Its role in facilitating the synthesis of peptides makes it an indispensable tool for researchers in the field.

InChI:InChI=1/C38H32N2O5/c39-35(41)24-34(36(42)43)40(37(44)45-25-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)38(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H2,39,41)(H,42,43)/t34-/m1/s1