180624-12-8

Basic information

• Product Name: 4,6-dimethyl-2-[2-(trimethylsilyl)ethynyl]aniline
• Synonyms: 4,6-dimethyl-2-[2-(trimethylsilyl)ethynyl]aniline
• CAS NO: 180624-12-8
• Molecular Weight: 217.386
• Mol File: 180624-12-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4,6-dimethyl-2-[2-(trimethylsilyl)ethynyl]aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dimethyl-2-[2-(trimethylsilyl)ethynyl]aniline(180624-12-8)
• EPA Substance Registry System: 4,6-dimethyl-2-[2-(trimethylsilyl)ethynyl]aniline(180624-12-8)

Safety Data

• Hazardous Substances Data: 180624-12-8(Hazardous Substances Data)

Upstream product

• 95-68-1 2,4-Xylidine 
• 4102-54-9 2-iodo-4,6-dimethylaniline 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1202474-66-5 2,4-dimethyl-6-(6,8-dimethyl-4-methyl-2-quinolinyl)phenylamine 
• 1616975-16-6 5,7-dimethyl-1-tosylindolin-3-one 
• 1616975-06-4 N-(2-ethynyl-4,6-dimethylphenyl)-4-methylbenzenesulfonamide 
• 180623-94-3 3-iodo-5,7-dimethyl-1H-indole 

Relevant articles and documents

Synthesis of 3-Methylthioindoles via Intramolecular Cyclization of 2-Alkynylanilines Mediated by DMSO/DMSO-d6 and SOCl2

The intramolecular cyclization of 2-alkynylanilines mediated by DMSO/SOCl2 was found to afford biologically interesting 3-methylthioindoles, which are rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated count

Revisiting the Gold-Catalyzed Dimerization of 2-Ethynylanilines: A Room-Temperature and Silver-Free Protocol for the Synthesis of Multifunctional Quinolines

A room temperature and silver-free protocol for the formation of quinolines from 2-ethynylanilines through a dimerization event was achieved using a dinuclear gold catalyst, Au2(BIPHEP)(NTf2)2. The reaction is inherently modular, allowing for the incorporation of peripheral substituents at any site of the quinoline product. The reaction is readily applied to other heterocyles also as exemplified by the preparation of naphthyridines. Competition reactions to determine the reactivity of dissimilar alkynes demonstrated that the product ratio of dimerization vs intermolecular addition is rather dependent on the electronic nature of aryl substituent on the alkynes. However, control experiments with substrates possessing internal alkynes resulted in cycloisomerization instead of expected dimerization, which is indicative of possible steric influence of the alkyne terminus in the reaction outcome.

TETRAHYDRO-BETA-CARBOLINE COMPOUNDS

The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are