180629-37-2

Basic information

• Product Name: (RS)-5-iodomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one
• Synonyms: (RS)-5-iodomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one
• CAS NO: 180629-37-2
• Molecular Weight: 331.153
• Mol File: 180629-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-5-iodomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-5-iodomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one(180629-37-2)
• EPA Substance Registry System: (RS)-5-iodomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one(180629-37-2)

Safety Data

• Hazardous Substances Data: 180629-37-2(Hazardous Substances Data)

Upstream product

• 180629-35-0 5-(hydroxymethyl)-1-(4-methoxyphenyl)pyrrolidin-2-one 
• 104-94-9 4-methoxy-aniline 
• 760-94-1 dimethyl-2-bromoglutarate 
• 180629-36-1 Methanesulfonic acid 1-(4-methoxy-phenyl)-5-oxo-pyrrolidin-2-ylmethyl ester 

Downstream Products

• 180629-10-1 1-(4-Methoxy-phenyl)-5-(2H-tetrazol-5-ylmethyl)-pyrrolidin-2-one 
• 180629-28-1 1-(4-Methoxy-phenyl)-5-(2-methyl-2H-tetrazol-5-ylmethyl)-pyrrolidin-2-one 
• 180629-38-3 (RS)-5-cyanomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one 

Relevant articles and documents

Simple and condensed β-lactams. Part 27. Reaction of 1-(4-methoxyphenyl)-4-(tetrazol-5-yl)azetidin-2-one and 1-(4-methoxyphenyl)-5-(tetrazol-5-yl-methyl)pyrrolidin-2-one with Cerium(IV) ammonium nitrate (CAN)

Treatment of pyrrolidinone 3a with CAN under the usual conditions leads to formation of spiro compound 12, rather than to N-demethoxyphenylation. A study of the reactions of compound 12 with sodium chloride and sodium iodide furnished the proof for our assumption that the related non-isolable compounds 6 and 11 are the intermediates of the anomalous reactions of compounds 1a and 2a, respectively, with CAN.