180631-67-8Relevant articles and documents
Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities
Huang, Wei,Sun, Xihuan,Li, Yunzhan,He, Zhixiang,Li, Li,Deng, Zhou,Huang, Xiaoxing,Han, Shang,Zhang, Ting,Zhong, Jiaji,Wang, Zheng,Xu, Qingyan,Zhang, Jianming,Deng, Xianming
supporting information, p. 5424 - 5434 (2018/06/18)
Methuosis is a novel nonapoptotic mode of cell death characterized by vacuole accumulation in the cytoplasm. In this article, we describe a series of azaindole-based compounds that cause vacuolization in MDA-MB-231 cells. The most potent vacuole inducer,
Pyrrolo[3,2-b ]quinoxaline derivatives as types I1/2 and II Eph tyrosine kinase inhibitors: Structure-based design, synthesis, and in vivo validation
Unzue, Andrea,Dong, Jing,Lafleur, Karine,Zhao, Hongtao,Frugier, Emilie,Caflisch, Amedeo,Nevado, Cristina
supporting information, p. 6834 - 6844 (2014/10/15)
The X-ray crystal structures of the catalytic domain of the EphA3 tyrosine kinase in complex with two type I inhibitors previously discovered in silico (compounds A and B) were used to design type I1/2 and II inhibitors. Chemical synthesis of a