180675-22-3

Basic information

• Product Name: (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE
• Synonyms: (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE;(1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMI DE, 1.0M SOLUTION IN THF;(1,3-dioxolan-2-ylmethyl)magnesium bromide solution;(1,3-Dioxolan-2-ylMethyl)MagnesiuM broMide, 0.5M solution in THF, AcroSeal;Bromo(1,3-dioxolan-2-ylmethyl)magnesium;MagnesiuM,broMo(1,3-dioxolan-2-ylMethyl)-;(1,3-Dioxolan-2-ylMethyl)MagnesiuM broMide solution 0.5 M in THF;1,3-Dioxolan-2-ylmethylmagnesium bromide, 0.50 M in THF
• CAS NO: 180675-22-3
• Molecular Formula: C4H7BrMgO2
• Molecular Weight: 191.31
• Product Categories: Alkyl;Grignard Reagents;Organometallic Reagents
• Mol File: 180675-22-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 65-67 °C
• Flash Point: −4 °F
• Appearance: White to off-white to pale brown/Powder
• Density: 0.938 g/mL at 25 °C
• Vapor Pressure: 87.6mmHg at 25°C
• CAS DataBase Reference: (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE(180675-22-3)
• EPA Substance Registry System: (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE(180675-22-3)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-40-37-36/37/38
• Safety Statements: 16-26-33-36-36/37/39-45-36/37
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 180675-22-3(Hazardous Substances Data)

Usage

Description

(1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE is a Grignard reagent, which is a type of organomagnesium compound. It is characterized by its ability to participate in various organic reactions, particularly in the formation of carbon-carbon bonds. This reagent is known for its versatility and is widely used in the synthesis of complex organic molecules.

Uses

Used in Pharmaceutical Industry:
(1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE is used as a synthetic intermediate for the preparation of 3-[11C]-Propionaldehyde, which is a key component in the synthesis of radiolabeled compound [11C]SN-38. SN-38 is a derivative of camptothecin, a potent chemotherapeutic agent used in the treatment of various cancers.
Used in Organic Synthesis:
(1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE is used as a reagent for the synthesis of 1-[(S)-2,2-Dimethyl-(1,3)-dioxolan-4-yl]-4-(1,3-dioxolan2-yl)-2-ol by reacting with D-glyceraldehyde. (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE is further utilized in the synthesis of unsaturated nucleosides, which are important in the development of new antiviral and anticancer drugs.
Used in Natural Product Synthesis:
In the field of natural product synthesis, (1,3-DIOXOLAN-2-YLMETHYL)MAGNESIUM BROMIDE is used as a key intermediate in the total synthesis of spirovibsanin A, a complex natural product with potential biological activities. The reagent's ability to form carbon-carbon bonds makes it a valuable tool in constructing the intricate structures of natural products.

InChI:InChI=1/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q-1;;+2/p-1