18075-64-4

Basic information

• Product Name: 1-Phenyl-1H-imidazole-4-carboxylic acid
• Synonyms: 1-Phenyl-1H-imidazole-4-carboxylic acid
• CAS NO: 18075-64-4
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.185
• Mol File: 18075-64-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 424.516°C at 760 mmHg
• Flash Point: 210.54°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.48±0.10(Predicted)
• CAS DataBase Reference: 1-Phenyl-1H-imidazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-1H-imidazole-4-carboxylic acid(18075-64-4)
• EPA Substance Registry System: 1-Phenyl-1H-imidazole-4-carboxylic acid(18075-64-4)

Safety Data

• Hazardous Substances Data: 18075-64-4(Hazardous Substances Data)

Usage

General Description

1-Phenyl-1H-imidazole-4-carboxylic acid, also known as PHICA, is a heterocyclic organic compound with a chemical structure containing both an imidazole ring and a carboxylic acid group. It is a white crystalline powder that is soluble in polar solvents, and it has potential applications in the field of medicine and pharmaceuticals. PHICA has been studied for its potential as an anti-inflammatory and antimicrobial agent, and it also has potential use in the synthesis of other organic compounds. Additionally, PHICA derivatives have been investigated for their potential as anticancer agents. Overall, 1-Phenyl-1H-imidazole-4-carboxylic acid is a versatile chemical with potential applications in various fields.

InChI:InChI=1/C10H8N2O2/c13-10(14)9-6-12(7-11-9)8-4-2-1-3-5-8/h1-7H,(H,13,14)

Upstream product

• 116343-89-6 methyl 1-phenyl-1H-imidazole-4-carboxylate 
• 197079-08-6 ethyl 1-phenyl-1H-imidazole-4-carboxylate 
• 591-50-4 iodobenzene 
• 103-70-8 Formanilid 
• 1197040-29-1 phenyl isocyanate 
• 62-53-3 aniline 

Downstream Products

• 1188373-49-0 1-phenyl-1H-imidazole-4-carboxylic acid {2-oxo-2-[4-(3-trifluoromethylphenoxy)piperidin-1-yl]ethyl}amide 
• 1188373-50-3 1-phenyl-1H-imidazole-4-carboxylic acid {2-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-2-oxoethyl}amide 
• 1188373-85-4 1-phenyl-1H-imidazole-4-carboxylic acid {2-[4-(2,5-difluorophenoxy)piperidin-1-yl]-2-oxoethyl}amide 
• 1232028-07-7 1-phenyl-1H-imidazole-4-carboxylic acid {2-[4-(2-chloro-5-fluoro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-amide 
• 1391625-85-6 (3S,6S)-3,6-diisobutyl-4-(1-phenyl-1H-imidazole-4-carbonyl)-piperazin-2-one 
• 1613022-33-5 C₂₁H₂₀N₆O*C₂HF₃O₂ 
• 1613022-32-4 1-phenyl-1H-imidazole-4-carboxylic acid (1-pyrrolo[1,2-a]pyrazin-1-yl-pyrrolidin-3-yl)amide 
• 1613022-35-7 1-phenyl-1H-imidazole-4-carboxylic acid[1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-yl]-amide 
• 1613021-87-6 (S)-N-(1-([1,2,4]triazolo[4,3-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-phenyl-1H-imidazole-4-carboxamide 

Relevant articles and documents

Novel Compounds

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.