1807518-77-9

Basic information

• Product Name: Fmoc-N-methyl-N-amido-PEG2-acid
• Synonyms: Fmoc-N-methyl-N-amido-PEG2-acid;Fmoc-N-methyl-N-amido-PEG2-COOH;Fmoc-NMe-PEG2-acid
• CAS NO: 1807518-77-9
• Molecular Formula: C23H27NO6
• Molecular Weight: 413.46358
• Mol File: 1807518-77-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 630.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• Solubility: Soluble in DMSO, DCM, DMF
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: Fmoc-N-methyl-N-amido-PEG2-acid(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-N-methyl-N-amido-PEG2-acid(1807518-77-9)
• EPA Substance Registry System: Fmoc-N-methyl-N-amido-PEG2-acid(1807518-77-9)

Safety Data

• Hazardous Substances Data: 1807518-77-9(Hazardous Substances Data)

Usage

Description

Fmoc-N-methyl-N-amido-PEG2-acid is a PEG-based linker molecule that features an Fmoc-protected amine and a terminal carboxylic acid. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic PEG spacer. The Fmoc group can be removed under basic conditions, revealing the free amine for subsequent conjugation reactions. The terminal carboxylic acid is capable of forming stable amide bonds with primary amine groups through the use of coupling agents such as EDC or HATU.

Uses

Used in Bioconjugation:
Fmoc-N-methyl-N-amido-PEG2-acid is used as a linker in bioconjugation processes for attaching various biomolecules, such as peptides, proteins, or other functional groups, to a target molecule. The Fmoc-protected amine allows for selective deprotection and subsequent conjugation, while the terminal carboxylic acid facilitates the formation of stable amide bonds with primary amines.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Fmoc-N-methyl-N-amido-PEG2-acid is used as a component in drug delivery systems to improve the solubility and stability of therapeutic agents. The PEG spacer can enhance the bioavailability and circulation time of drugs in the body, while the Fmoc-protected amine and terminal carboxylic acid provide sites for attaching drug molecules or other functional groups.
Used in Chemical Synthesis:
Fmoc-N-methyl-N-amido-PEG2-acid is utilized as an intermediate in the synthesis of complex organic molecules, particularly in the development of new pharmaceuticals or bioactive compounds. The molecule's functional groups allow for a variety of chemical reactions, enabling the creation of diverse molecular structures with potential applications in various fields.