180973-42-6

Basic information

• Product Name: N-[(9-fluorenylmethoxy)carbonyl]-L-threonyl-L-valine methyl ester
• Synonyms: N-[(9-fluorenylmethoxy)carbonyl]-L-threonyl-L-valine methyl ester
• CAS NO: 180973-42-6
• Molecular Weight: 454.523
• Mol File: 180973-42-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[(9-fluorenylmethoxy)carbonyl]-L-threonyl-L-valine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(9-fluorenylmethoxy)carbonyl]-L-threonyl-L-valine methyl ester(180973-42-6)
• EPA Substance Registry System: N-[(9-fluorenylmethoxy)carbonyl]-L-threonyl-L-valine methyl ester(180973-42-6)

Safety Data

• Hazardous Substances Data: 180973-42-6(Hazardous Substances Data)

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 73731-37-0 Fmoc-Thr-OH 
• 4070-48-8 L-Valine methyl ester 

Downstream Products

• 128517-07-7 romidepsin 
• 180973-32-4 (S)-2-{(Z)-2-[(S)-2-((R)-2-Amino-3-methyl-butyrylamino)-3-tritylsulfanyl-propionylamino]-but-2-enoylamino}-3-methyl-butyric acid methyl ester 
• 180973-28-8 (S)-2-{(2S,3R)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-3-hydroxy-butyrylamino}-3-methyl-butyric acid methyl ester 
• 180973-30-2 (S)-2-((2S,3R)-2-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-3-hydroxy-butyrylamino)-3-methyl-butyric acid methyl ester 
• 180973-35-7 (3S,9S,12R,16S)-6-eth-(Z)-ylidene-3,12-diisopropyl-16-((E)-4-tritylsulfanyl-but-1-enyl)-9-tritylsulfanylmethyl-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone 
• 180973-31-3 (S)-2-[(2S,3R)-2-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-3-(toluene-4-sulfonyloxy)-butyrylamino]-3-methyl-butyric acid methyl ester 
• 180973-34-6 (5E,7S,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid 
• 181141-25-3 (5E,7R,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid 
• 180973-33-5 (5E,7S,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate 
• 181141-24-2 (5E,7R,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate 

Relevant articles and documents

Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228)

A scaleable synthesis of the potent histone deacetylase (HDAC) inhibitor FK228 is described. A reliable strategy for preparing the key β-hydroxy mercapto heptenoic acid partner was accomplished in nine steps and 13% overall yield. A Noyori asymmetric hydrogen-transfer reaction established the hydroxyl stereochemistry in >99:1 er via the reduction of a propargylic ketone.