180976-98-1

Basic information

• Product Name: BOC-4-AMINO-3-METHOXYBENZOIC ACID
• Synonyms: BOC-4-AMINO-3-METHOXYBENZOIC ACID;4-tert-ButoxycarbonylaMino-3-Methoxy-benzoic acid;4-(Boc-amino)-3-methoxybenzoic acid
• CAS NO: 180976-98-1
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.28
• Mol File: 180976-98-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 371.3±32.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.21±0.10(Predicted)
• CAS DataBase Reference: BOC-4-AMINO-3-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-4-AMINO-3-METHOXYBENZOIC ACID(180976-98-1)
• EPA Substance Registry System: BOC-4-AMINO-3-METHOXYBENZOIC ACID(180976-98-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 180976-98-1(Hazardous Substances Data)

Usage

General Description

BOC-4-AMINO-3-METHOXYBENZOIC ACID is a chemical compound with the molecular formula C11H13NO4. It is a derivative of benzoic acid and contains a Boc (tert-butoxycarbonyl) protecting group attached to the amino group. BOC-4-AMINO-3-METHOXYBENZOIC ACID is often used in organic synthesis as a building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is commonly utilized as a key intermediate in the synthesis of various biologically active compounds and is known for its diverse applications in the fields of medicinal chemistry and drug discovery.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2486-69-3 3-methoxy-4-aminobenzoic acid 
• 941715-64-6 C₁₄H₁₉NO₅ 
• 941715-62-4 methyl 4-(t-butoxycarbonylamino)-3-hydroxybenzoate 
• 63435-16-5 3-hydroxy-4-aminobenzoic acid methyl ester 

Downstream Products

• 180976-99-2 N-BOC-4-amino-3-methoxybenzoyl methionine methyl ester 
• 941715-77-1 C₂₁H₂₄N₂O₇ 
• 941715-78-2 C₂₈H₃₀N₂O₇ 
• 1058114-52-5 C₂₇H₂₈N₂O₇ 
• 941715-79-3 C₃₅H₃₅N₃O₉ 
• 180977-01-9 (S)-2-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methoxy-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester 
• 1253936-76-3 C₃₁H₃₆N₄O₅ 
• 876126-60-2 4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 

Relevant articles and documents

Synthesis and biological evaluation of 2,4-diaminopyrimidines as selective Aurora A kinase inhibitors

The Aurora kinases are a family of serine/threonine kinases that interact with components of the mitotic apparatus and serve as potential therapeutic targets in oncology. Here we synthesized 15 2,4-diaminopyrimidines and evaluated their biological activities, including antiproliferation, inhibition against Aurora kinases and cell cycle effects. These compounds generally exhibited more potent cytotoxicity against tumor cell lines compared with the VX-680 control, especially compound 11c, which showed the highest cytotoxicities, with IC50 values of 0.5-4.0 1/4M. Compound 11c had more than 35-fold more selectivity for Aurora A over Aurora B, and molecular docking analysis indicated that compound 11c form better interaction with Aurora A both from the perspective of structure and energy. Furthermore, compound 11c induced G2/M cell cycle arrest in HeLa cells. This series of compounds has the potential for further development as selective Aurora A inhibitors for anticancer activity.

Facile synthesis of benzamides to mimic an α-helix

A new α-helix mimetic was designed by using a benzamide as a rigid scaffold. It presents three functional groups corresponding to side chains of amino acids found at the i, i + 4, and i + 7 positions of an ideal α-helix, which are displayed on the same he

Inhibitors of prenyl transferases

Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.