181058-43-5

Basic information

• Product Name: ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
• Synonyms: ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
• CAS NO: 181058-43-5
• Molecular Weight: 350.826
• Mol File: 181058-43-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate(181058-43-5)
• EPA Substance Registry System: ethyl 5-(4-chlorophenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate(181058-43-5)

Safety Data

• Hazardous Substances Data: 181058-43-5(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 154866-92-9 ethyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 154866-92-9 ethyl 6-methyl-4-(4-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 181058-45-7 5-(4-Chloro-phenyl)-2-[1-(2-chloro-phenyl)-meth-(Z)-ylidene]-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 423745-93-1 2-(4-((5-(4-chlorophenyl)-6-(ethoxycarbonyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidin-2-ylidene)methyl)phenoxy)acetic acid 
• 154867-11-5 5-(4-Chloro-phenyl)-2-[1-(4-dimethylamino-phenyl)-meth-(Z)-ylidene]-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 181058-44-6 5-(4-Chloro-phenyl)-2-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

Biological evaluation of halogenated thiazolo[3,2-a]pyrimidin-3-one carboxylic acid derivatives targeting the YycG histidine kinase

With an intention to potent inhibitors of YycG histidine kinase, a series of halogenated thiazolo[3,2-a]pyrimidin-3-one carboxylic acid derivatives were synthesized and evaluated for their antibacterial, antibiofilm and hemolytic activities. The majority of the compounds showed good activity against Staphylococcus epidermidis and Staphylococcus aureus, with MIC values of 1.56-6.25 μM, simultaneously presented promising antiobifilm activity against S. epidermidis ATCC35984 at 50 μM. The test of inhibitory activity on YycG kinase suggested the antibacterial activities of these derivatives are based on inhibiting the enzyme activity of the YycG HK domain. The hemolytic activity test suggested these compounds exhibited in vitro antibacterial activity at non-hemolytic concentrations.

Synthesis and radiation stability of novel thiazolopyrimidines with expected antifungal activity

A number of thiazolopyrimidines (II-VII) were prepared through interaction of 6-methyl-4(4′-chlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carboxylic acid ethyl ester (Ia) with many reagents. The antifungal activity of all prepared compounds have been determined using Dithane M-45 as a standard fungicide. Some compounds showed a high fungicidal activity equivalent to that of the standard towards Aspergillus niger and Aspergillus ochraceus. Also some biologically active compounds were subjected to gamma irradiation and the structures are stable.